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Statements

Subject Item
n2:RIV%2F00216224%3A14310%2F14%3A00075127%21RIV15-MSM-14310___
rdf:type
n7:Vysledek skos:Concept
dcterms:description
Mass spectrometry (MS) of complex biomolecules is mostly performed using Matrix-Assisted Laser Desorption Ionization (MALDI) with Time of Flight (TOF) detection. Development of nanotechnology and nanomaterials (NMs) and nanoparticles (NPs) with their unique physical and chemical properties brought to MS alternative media for efficient ionization of analytes and accelerated development of Surface-Assisted Laser Desorption Ionization (SALDI), Surface-Enhanced Laser Desorption Ionization (SELDI) and Nano-Assisted Laser Desorption Ionization (NALDI). These techniques contributed significantly to MS [1]. NMs possess also extensive applications in MALDI TOF MS tissue imaging in current nanomedicine [2]. In this work, we studied applications of various NMs (either as matrices or surfaces) in MS analysis of histological tissue sections. We also evaluated effect of NMs on the ionization of various peptides and the comparison with common organic matrices was done. Mass spectrometry (MS) of complex biomolecules is mostly performed using Matrix-Assisted Laser Desorption Ionization (MALDI) with Time of Flight (TOF) detection. Development of nanotechnology and nanomaterials (NMs) and nanoparticles (NPs) with their unique physical and chemical properties brought to MS alternative media for efficient ionization of analytes and accelerated development of Surface-Assisted Laser Desorption Ionization (SALDI), Surface-Enhanced Laser Desorption Ionization (SELDI) and Nano-Assisted Laser Desorption Ionization (NALDI). These techniques contributed significantly to MS [1]. NMs possess also extensive applications in MALDI TOF MS tissue imaging in current nanomedicine [2]. In this work, we studied applications of various NMs (either as matrices or surfaces) in MS analysis of histological tissue sections. We also evaluated effect of NMs on the ionization of various peptides and the comparison with common organic matrices was done.
dcterms:title
Use of nanomaterials for TOF mass spectrometry of complex biomolecules and for tissue profiling Use of nanomaterials for TOF mass spectrometry of complex biomolecules and for tissue profiling
skos:prefLabel
Use of nanomaterials for TOF mass spectrometry of complex biomolecules and for tissue profiling Use of nanomaterials for TOF mass spectrometry of complex biomolecules and for tissue profiling
skos:notation
RIV/00216224:14310/14:00075127!RIV15-MSM-14310___
n3:aktivita
n9:Z n9:P
n3:aktivity
P(ED2.1.00/03.0086), Z(MSM0021622411)
n3:dodaniDat
n16:2015
n3:domaciTvurceVysledku
n4:6955231 n4:2074559 n4:8064296 n4:6723381
n3:druhVysledku
n14:O
n3:duvernostUdaju
n12:S
n3:entitaPredkladatele
n6:predkladatel
n3:idSjednocenehoVysledku
52316
n3:idVysledku
RIV/00216224:14310/14:00075127
n3:jazykVysledku
n17:eng
n3:klicovaSlova
MALDI MS; Nanotechnology; Nanoparticles; Nanoflowers; Tissue profiling
n3:klicoveSlovo
n10:Nanotechnology n10:Tissue%20profiling n10:Nanoflowers n10:Nanoparticles n10:MALDI%20MS
n3:kontrolniKodProRIV
[63C61AC4123C]
n3:obor
n18:CB
n3:pocetDomacichTvurcuVysledku
4
n3:pocetTvurcuVysledku
6
n3:projekt
n11:ED2.1.00%2F03.0086
n3:rokUplatneniVysledku
n16:2014
n3:tvurceVysledku
Puig Romero, Mireia Kolářová, Lenka Vaňhara, Petr Hampl, Aleš Salvado, Victoria Havel, Josef
n3:zamer
n8:MSM0021622411
n15:organizacniJednotka
14310