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Statements

Subject Item
n2:RIV%2F00216224%3A14310%2F14%3A00075111%21RIV15-MSM-14310___
rdf:type
skos:Concept n17:Vysledek
rdfs:seeAlso
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3900522/
dcterms:description
Cancer is a major public health problem worldwide. In the United States alone, 1 in 4 deaths is due to cancer and for 2013 a total of 1,660,290 new cancer cases and 580,350 cancer-related deaths are projected. Comprehensive profiling of multiple cancer genomes has revealed a highly complex genetic landscape in which a large number of altered genes, varying from tumor to tumor, impact core biological pathways and processes. This has implications for therapeutic targeting of signaling networks in the development of treatments for specific cancers. The NFkappaB transcription factor is constitutively active in a number of hematologic and solid tumors, and many signaling pathways implicated in cancer are likely connected to NFkappaB activation. A critical mediator of NFkappaB activity is TGFbeta-activated kinase 1 (TAK1). Here, we identify TAK1 as a novel interacting protein and target of fibroblast growth factor receptor 3 (FGFR3) tyrosine kinase activity. Cancer is a major public health problem worldwide. In the United States alone, 1 in 4 deaths is due to cancer and for 2013 a total of 1,660,290 new cancer cases and 580,350 cancer-related deaths are projected. Comprehensive profiling of multiple cancer genomes has revealed a highly complex genetic landscape in which a large number of altered genes, varying from tumor to tumor, impact core biological pathways and processes. This has implications for therapeutic targeting of signaling networks in the development of treatments for specific cancers. The NFkappaB transcription factor is constitutively active in a number of hematologic and solid tumors, and many signaling pathways implicated in cancer are likely connected to NFkappaB activation. A critical mediator of NFkappaB activity is TGFbeta-activated kinase 1 (TAK1). Here, we identify TAK1 as a novel interacting protein and target of fibroblast growth factor receptor 3 (FGFR3) tyrosine kinase activity.
dcterms:title
Fibroblast Growth Factor Receptor 3 Interacts with and Activates TGFbeta-Activated Kinase 1 Tyrosine Phosphorylation and NFkappaB Signaling in Multiple Myeloma and Bladder Cancer Fibroblast Growth Factor Receptor 3 Interacts with and Activates TGFbeta-Activated Kinase 1 Tyrosine Phosphorylation and NFkappaB Signaling in Multiple Myeloma and Bladder Cancer
skos:prefLabel
Fibroblast Growth Factor Receptor 3 Interacts with and Activates TGFbeta-Activated Kinase 1 Tyrosine Phosphorylation and NFkappaB Signaling in Multiple Myeloma and Bladder Cancer Fibroblast Growth Factor Receptor 3 Interacts with and Activates TGFbeta-Activated Kinase 1 Tyrosine Phosphorylation and NFkappaB Signaling in Multiple Myeloma and Bladder Cancer
skos:notation
RIV/00216224:14310/14:00075111!RIV15-MSM-14310___
n4:aktivita
n12:S
n4:aktivity
S
n4:cisloPeriodika
1
n4:dodaniDat
n9:2015
n4:domaciTvurceVysledku
n18:5512646
n4:druhVysledku
n14:J
n4:duvernostUdaju
n16:S
n4:entitaPredkladatele
n6:predkladatel
n4:idSjednocenehoVysledku
16691
n4:idVysledku
RIV/00216224:14310/14:00075111
n4:jazykVysledku
n8:eng
n4:klicovaSlova
FGFR3; TAK1; NFkappaB; multiple myeloma; bladder cancer
n4:klicoveSlovo
n5:FGFR3 n5:NFkappaB n5:bladder%20cancer n5:multiple%20myeloma n5:TAK1
n4:kodStatuVydavatele
US - Spojené státy americké
n4:kontrolniKodProRIV
[3D2F6125660B]
n4:nazevZdroje
PLOS ONE
n4:obor
n13:ED
n4:pocetDomacichTvurcuVysledku
1
n4:pocetTvurcuVysledku
9
n4:rokUplatneniVysledku
n9:2014
n4:svazekPeriodika
9
n4:tvurceVysledku
Donoghue, Daniel Casale, Malcolm Hallowell, Matthew Salazar, Lisa Krejčí, Pavel Michels Thompson, Leslie Meyer, April Wilcox, William Kashiwada, Tamar
n4:wos
000330288000101
s:issn
1932-6203
s:numberOfPages
13
n11:doi
10.1371/journal.pone.0086470
n10:organizacniJednotka
14310