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Statements

Subject Item
n2:RIV%2F00216224%3A14310%2F14%3A00074976%21RIV15-MSM-14310___
rdf:type
skos:Concept n18:Vysledek
dcterms:description
Transgelin is an abundant protein of smooth muscle cells, where its role has been primarily studied. As a protein affecting dynamics of the actin cytoskeleton via stabilization of actin filaments, transgelin is both directly and indirectly involved in many cancer-related processes such as migration, proliferation, differentiation or apoptosis. Transgelin was previously reviewed as a tumor suppressor; however, recent data based on a number of proteomics studies indicate its pro-tumorigenic role, for example, in colorectal or hepatocellular cancer. We summarize these contradictory observations in both clinical and functional proteomics projects and analyze the role of transgelin in tumors in detail. Generally, the expression and biological role of transgelin seem to differ among various types of tumor cells and stroma, and possibly change during tumor progression. Transgelin is an abundant protein of smooth muscle cells, where its role has been primarily studied. As a protein affecting dynamics of the actin cytoskeleton via stabilization of actin filaments, transgelin is both directly and indirectly involved in many cancer-related processes such as migration, proliferation, differentiation or apoptosis. Transgelin was previously reviewed as a tumor suppressor; however, recent data based on a number of proteomics studies indicate its pro-tumorigenic role, for example, in colorectal or hepatocellular cancer. We summarize these contradictory observations in both clinical and functional proteomics projects and analyze the role of transgelin in tumors in detail. Generally, the expression and biological role of transgelin seem to differ among various types of tumor cells and stroma, and possibly change during tumor progression.
dcterms:title
Transgelins, cytoskeletal proteins implicated in different aspects of cancer development Transgelins, cytoskeletal proteins implicated in different aspects of cancer development
skos:prefLabel
Transgelins, cytoskeletal proteins implicated in different aspects of cancer development Transgelins, cytoskeletal proteins implicated in different aspects of cancer development
skos:notation
RIV/00216224:14310/14:00074976!RIV15-MSM-14310___
n4:aktivita
n14:S n14:P n14:I
n4:aktivity
I, P(ED2.1.00/03.0101), S
n4:cisloPeriodika
2
n4:dodaniDat
n7:2015
n4:domaciTvurceVysledku
n8:2765985 n8:2503786
n4:druhVysledku
n12:J
n4:duvernostUdaju
n9:S
n4:entitaPredkladatele
n16:predkladatel
n4:idSjednocenehoVysledku
51022
n4:idVysledku
RIV/00216224:14310/14:00074976
n4:jazykVysledku
n19:eng
n4:klicovaSlova
cancer; cytoskeleton; differentiation; proliferation; transgelin; transgelin-2
n4:klicoveSlovo
n5:cancer n5:cytoskeleton n5:differentiation n5:proliferation n5:transgelin n5:transgelin-2
n4:kodStatuVydavatele
GB - Spojené království Velké Británie a Severního Irska
n4:kontrolniKodProRIV
[3BADA50099C4]
n4:nazevZdroje
Expert Review of Proteomics
n4:obor
n10:CE
n4:pocetDomacichTvurcuVysledku
2
n4:pocetTvurcuVysledku
3
n4:projekt
n13:ED2.1.00%2F03.0101
n4:rokUplatneniVysledku
n7:2014
n4:svazekPeriodika
11
n4:tvurceVysledku
Nenutil, Rudolf Bouchal, Pavel Dvořáková, Monika
n4:wos
000335649300004
s:issn
1478-9450
s:numberOfPages
17
n15:doi
10.1586/14789450.2014.860358
n17:organizacniJednotka
14310