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Statements

Subject Item
n2:RIV%2F00216224%3A14310%2F14%3A00074892%21RIV15-MSM-14310___
rdf:type
n12:Vysledek skos:Concept
dcterms:description
Epidermal growth factor receptor (EGFR) gene amplification and the overexpression of EGFR are described as common features of glioblastoma multiforme (GBM). Nevertheless, we previously reported the loss of EGFR gene copy in a GBM specimen from a patient with an unusually favorable course of the disease, and the HGG-02 cell line with this aberration was successfully derived from this tumor. Here, we present a detailed analysis of changes in gene expression and cell signaling in the HGG-02 cell line; the GM7 reference cell line with a standard EGFR gene copy number derived from a very aggressive GBM was used as a control. We confirmed the downregulation of EGFR expression and signaling in HGG-02 cells using different methods (RTK analysis, gene profiling and RT-PCR). Other changes that may have contributed to the non-aggressive phenotype of the primary tumor were identified, including the downregulated phosphorylation of the Axl and Trk receptors, as well as increased activity of JNK and p38 kinases. Epidermal growth factor receptor (EGFR) gene amplification and the overexpression of EGFR are described as common features of glioblastoma multiforme (GBM). Nevertheless, we previously reported the loss of EGFR gene copy in a GBM specimen from a patient with an unusually favorable course of the disease, and the HGG-02 cell line with this aberration was successfully derived from this tumor. Here, we present a detailed analysis of changes in gene expression and cell signaling in the HGG-02 cell line; the GM7 reference cell line with a standard EGFR gene copy number derived from a very aggressive GBM was used as a control. We confirmed the downregulation of EGFR expression and signaling in HGG-02 cells using different methods (RTK analysis, gene profiling and RT-PCR). Other changes that may have contributed to the non-aggressive phenotype of the primary tumor were identified, including the downregulated phosphorylation of the Axl and Trk receptors, as well as increased activity of JNK and p38 kinases.
dcterms:title
EGFR signaling in the HGG-02 glioblastoma cell line with an unusual loss of EGFR gene copy EGFR signaling in the HGG-02 glioblastoma cell line with an unusual loss of EGFR gene copy
skos:prefLabel
EGFR signaling in the HGG-02 glioblastoma cell line with an unusual loss of EGFR gene copy EGFR signaling in the HGG-02 glioblastoma cell line with an unusual loss of EGFR gene copy
skos:notation
RIV/00216224:14310/14:00074892!RIV15-MSM-14310___
n3:aktivita
n13:P
n3:aktivity
P(ED2.1.00/03.0101), P(EE2.3.20.0183)
n3:cisloPeriodika
1
n3:dodaniDat
n6:2015
n3:domaciTvurceVysledku
n5:1195271 n5:9637915 n5:1398954 n5:6366252 n5:5658179
n3:druhVysledku
n14:J
n3:duvernostUdaju
n8:S
n3:entitaPredkladatele
n19:predkladatel
n3:idSjednocenehoVysledku
13882
n3:idVysledku
RIV/00216224:14310/14:00074892
n3:jazykVysledku
n18:eng
n3:klicovaSlova
glioblastoma multiforme; epidermal growth factor receptor signaling; PDGFR; TAM receptors; receptor tyrosine kinase; mitogen-activated protein kinase
n3:klicoveSlovo
n7:receptor%20tyrosine%20kinase n7:glioblastoma%20multiforme n7:epidermal%20growth%20factor%20receptor%20signaling n7:PDGFR n7:TAM%20receptors n7:mitogen-activated%20protein%20kinase
n3:kodStatuVydavatele
GR - Řecká republika
n3:kontrolniKodProRIV
[8DB74939EF87]
n3:nazevZdroje
Oncology Reports
n3:obor
n4:EB
n3:pocetDomacichTvurcuVysledku
5
n3:pocetTvurcuVysledku
5
n3:projekt
n16:EE2.3.20.0183 n16:ED2.1.00%2F03.0101
n3:rokUplatneniVysledku
n6:2014
n3:svazekPeriodika
31
n3:tvurceVysledku
Zitterbart, Karel Veselská, Renata Škoda, Jan Štěrba, Jaroslav Neradil, Jakub
n3:wos
000330788100065
s:issn
1021-335X
s:numberOfPages
8
n11:doi
10.3892/or.2013.2864
n9:organizacniJednotka
14310