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Statements

Subject Item
n2:RIV%2F00216224%3A14310%2F14%3A00073621%21RIV15-MSM-14310___
rdf:type
skos:Concept n17:Vysledek
dcterms:description
Investigating the functions of various bioactive molecules produced by parasites expands our understanding of the principles of host-parasite interaction. Several of these compounds were proven to play a key role in a manipulation of the host immune system and thus maximizing the parasite success; among them also the cysteine peptidase inhibitors (CPI) were recorded. Our work is focused on characterization of the properties of CPI expressed by four helminth model species representing four big taxonomic groups – Monogenea, Cestoda, Trematoda and Nematoda. Prior to the functional analysis we searched the transcriptomic and/or genomic data of Eudiplozoon nipponicum, Hymenolepis diminuta, Fascioloides magna and Trichinella spiralis for the presence of conserved cystatin domains. We identified distinct families of CPI (stefins, cystatins and kininogens) and observed differences among the studied species. We designed specific/degenerate primers; amplified, cloned and sequenced the selected genes. Investigating the functions of various bioactive molecules produced by parasites expands our understanding of the principles of host-parasite interaction. Several of these compounds were proven to play a key role in a manipulation of the host immune system and thus maximizing the parasite success; among them also the cysteine peptidase inhibitors (CPI) were recorded. Our work is focused on characterization of the properties of CPI expressed by four helminth model species representing four big taxonomic groups – Monogenea, Cestoda, Trematoda and Nematoda. Prior to the functional analysis we searched the transcriptomic and/or genomic data of Eudiplozoon nipponicum, Hymenolepis diminuta, Fascioloides magna and Trichinella spiralis for the presence of conserved cystatin domains. We identified distinct families of CPI (stefins, cystatins and kininogens) and observed differences among the studied species. We designed specific/degenerate primers; amplified, cloned and sequenced the selected genes.
dcterms:title
Cysteine peptidase inhibitors of helminths Cysteine peptidase inhibitors of helminths
skos:prefLabel
Cysteine peptidase inhibitors of helminths Cysteine peptidase inhibitors of helminths
skos:notation
RIV/00216224:14310/14:00073621!RIV15-MSM-14310___
n3:aktivita
n15:S n15:P
n3:aktivity
P(GAP506/12/1258), P(GBP505/12/G112), S
n3:dodaniDat
n8:2015
n3:domaciTvurceVysledku
n5:1604422 n5:2900041 n5:6048412 n5:4591704
n3:druhVysledku
n13:O
n3:duvernostUdaju
n10:S
n3:entitaPredkladatele
n11:predkladatel
n3:idSjednocenehoVysledku
9531
n3:idVysledku
RIV/00216224:14310/14:00073621
n3:jazykVysledku
n4:eng
n3:klicovaSlova
cysteine peptidase inhibitors; helminths; immunomodulation
n3:klicoveSlovo
n14:cysteine%20peptidase%20inhibitors n14:helminths n14:immunomodulation
n3:kontrolniKodProRIV
[6009BC213CE1]
n3:obor
n16:EG
n3:pocetDomacichTvurcuVysledku
4
n3:pocetTvurcuVysledku
4
n3:projekt
n9:GBP505%2F12%2FG112 n9:GAP506%2F12%2F1258
n3:rokUplatneniVysledku
n8:2014
n3:tvurceVysledku
Koudela, Břetislav Ilgová, Jana Kašný, Martin Gelnar, Milan
n12:organizacniJednotka
14310