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Statements

Subject Item
n2:RIV%2F00216224%3A14310%2F13%3A00072736%21RIV14-MSM-14310___
rdf:type
n13:Vysledek skos:Concept
dcterms:description
The present invention relates to a method of thermostabilization of a protein and/or stabilization of a protein towards organic solvents wherein the protein contains access routes, wherein at least one amino acid in the bottleneck of the access route of the protein is mutated. Preferably, the method comprises the steps of identification of amino acids forming the bottleneck of the access routes, wherein said amino acids control the exchange of the solvent between the buried protein core and the surrounding environment and/or in the packing of the amino acids inside the access route; modification of the amino acids determined in the previous step so that the packing of the amino acids inside the tunnel is improved and the access route prevents the access of the undesired solvent molecules to the protein core, while it allows the passage of the compounds necessary at the protein core to enable the protein to perform its biological function. The present invention relates to a method of thermostabilization of a protein and/or stabilization of a protein towards organic solvents wherein the protein contains access routes, wherein at least one amino acid in the bottleneck of the access route of the protein is mutated. Preferably, the method comprises the steps of identification of amino acids forming the bottleneck of the access routes, wherein said amino acids control the exchange of the solvent between the buried protein core and the surrounding environment and/or in the packing of the amino acids inside the access route; modification of the amino acids determined in the previous step so that the packing of the amino acids inside the tunnel is improved and the access route prevents the access of the undesired solvent molecules to the protein core, while it allows the passage of the compounds necessary at the protein core to enable the protein to perform its biological function.
dcterms:title
Method of Thermostabilization of a Protein And/or Stabilization Towards Organic Solvents Method of Thermostabilization of a Protein And/or Stabilization Towards Organic Solvents
skos:prefLabel
Method of Thermostabilization of a Protein And/or Stabilization Towards Organic Solvents Method of Thermostabilization of a Protein And/or Stabilization Towards Organic Solvents
skos:notation
RIV/00216224:14310/13:00072736!RIV14-MSM-14310___
n13:predkladatel
n16:orjk%3A14310
n3:aktivita
n9:I n9:P
n3:aktivity
I, P(ED0001/01/01)
n3:cisloPatentuVzoru
US 8,580,932
n3:datumUdeleniPatentuVzoru
2013-11-12+01:00
n3:dodaniDat
n6:2014
n3:domaciTvurceVysledku
n10:6084559 n10:7612656 n10:2070103 n10:3599019 n10:1030175 n10:1713140
n3:druhVysledku
n20:P
n3:duvernostUdaju
n4:S
n3:entitaPredkladatele
n11:predkladatel
n3:idSjednocenehoVysledku
87569
n3:idVysledku
RIV/00216224:14310/13:00072736
n3:jazykVysledku
n17:eng
n3:klicovaSlova
Thermostabilization; Protein Stabilization; Organic Solvents
n3:klicoveSlovo
n12:Thermostabilization n12:Protein%20Stabilization n12:Organic%20Solvents
n3:kontrolniKodProRIV
[B87F20DF72ED]
n3:licencniPoplatek
n23:Z
n3:mistoVydaniPatentuVzoru
Alexandria
n3:nazevVydavatelePatentuVzoru
United States Patent and Trademark Office (USPTO)
n3:obor
n18:CE
n3:pocetDomacichTvurcuVysledku
6
n3:pocetTvurcuVysledku
8
n3:projekt
n14:ED0001%2F01%2F01
n3:rokUplatneniVysledku
n6:2013
n3:statVydaniPatentuVzoru
n21:US
n3:tvurceVysledku
Chovancová, Eva Štěpánková, Veronika Chaloupková, Radka Brezovský, Jan Koudeláková, Táňa Damborský, Jiří Gora, Artur Wiktor Prokop, Zbyněk
n3:uzemniOchranaPatentu
n7:B
n3:vlastnik
n11:vlastnikVysledku
n3:vyuzitiJinymSubjektem
n22:A
n3:vyuzitiPatentuVzoru
n8:B
n3:vlastnikPatentuVzoru
MU
n19:organizacniJednotka
14310