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Statements

Subject Item
n2:RIV%2F00216224%3A14310%2F13%3A00066176%21RIV14-GA0-14310___
rdf:type
skos:Concept n13:Vysledek
dcterms:description
In the paper we indicate the increasing importance of derivatives containing a dihydropyrrolo[1,2-b]pyrazole (DPP) core. We try to show our synthetic approach based on an improved Kulinkovich method as well as our new synthetic pathway. A complex methodology involving the preparation of substituted DPPs focuses on withasomnine and the synthesis of several structurally related compounds. The developed reaction protocols enable the preparation of the mentioned bicyclic system with broadly diverse substitution. Thus, we are able to prepare systems with aliphatic, aromatic, polyaromatic, heteroaromatic, TMS, and even adamantane substitution with known biologically active properties. The reaction protocol, consisting of two multi-step synthetic pathways, includes Sonogashira and Suzuki-Miyaura cross-coupling reactions, allenyl synthon formation, Kulinkovich cyclopropanation, ring transformations, and nonsymmetrical homoallenyl azines cycloadditions. In the paper we indicate the increasing importance of derivatives containing a dihydropyrrolo[1,2-b]pyrazole (DPP) core. We try to show our synthetic approach based on an improved Kulinkovich method as well as our new synthetic pathway. A complex methodology involving the preparation of substituted DPPs focuses on withasomnine and the synthesis of several structurally related compounds. The developed reaction protocols enable the preparation of the mentioned bicyclic system with broadly diverse substitution. Thus, we are able to prepare systems with aliphatic, aromatic, polyaromatic, heteroaromatic, TMS, and even adamantane substitution with known biologically active properties. The reaction protocol, consisting of two multi-step synthetic pathways, includes Sonogashira and Suzuki-Miyaura cross-coupling reactions, allenyl synthon formation, Kulinkovich cyclopropanation, ring transformations, and nonsymmetrical homoallenyl azines cycloadditions.
dcterms:title
Dihydropyrrolo[1,2-b]pyrazoles: withasomnine and related compounds Dihydropyrrolo[1,2-b]pyrazoles: withasomnine and related compounds
skos:prefLabel
Dihydropyrrolo[1,2-b]pyrazoles: withasomnine and related compounds Dihydropyrrolo[1,2-b]pyrazoles: withasomnine and related compounds
skos:notation
RIV/00216224:14310/13:00066176!RIV14-GA0-14310___
n13:predkladatel
n18:orjk%3A14310
n5:aktivita
n14:P
n5:aktivity
P(GA203/09/1345)
n5:cisloPeriodika
34
n5:dodaniDat
n8:2014
n5:domaciTvurceVysledku
n9:2333368 n9:1694928 n9:7689039 n9:2015501
n5:druhVysledku
n15:J
n5:duvernostUdaju
n17:S
n5:entitaPredkladatele
n19:predkladatel
n5:idSjednocenehoVysledku
69733
n5:idVysledku
RIV/00216224:14310/13:00066176
n5:jazykVysledku
n10:eng
n5:klicovaSlova
allenyl azine; withasomnine; cycloaddition; dihydropyrrolo[1.2-b]pyrazole; Kulinkovich
n5:klicoveSlovo
n12:allenyl%20azine n12:Kulinkovich n12:withasomnine n12:dihydropyrrolo%5B1.2-b%5Dpyrazole n12:cycloaddition
n5:kodStatuVydavatele
GB - Spojené království Velké Británie a Severního Irska
n5:kontrolniKodProRIV
[A2260F918BDA]
n5:nazevZdroje
Tetrahedron
n5:obor
n7:CC
n5:pocetDomacichTvurcuVysledku
4
n5:pocetTvurcuVysledku
4
n5:projekt
n16:GA203%2F09%2F1345
n5:rokUplatneniVysledku
n8:2013
n5:svazekPeriodika
69
n5:tvurceVysledku
Man, Stanislav Galeta, Juraj Potáček, Milan Tenora, Lukáš
n5:wos
000322098000028
s:issn
0040-4020
s:numberOfPages
8
n6:doi
10.1016/j.tet.2013.06.009
n20:organizacniJednotka
14310