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Statements

Subject Item
n2:RIV%2F00216224%3A14310%2F13%3A00066011%21RIV14-MSM-14310___
rdf:type
skos:Concept n8:Vysledek
dcterms:description
Novel approach to functionalized polycyclic aromatic hydrocarbons (PAHs) is presented. Incorporation of cyclic nitrone framework into the structure of PAHs was studied with respect to their anti-proliferative activities and interaction with double stranded DNA. Theoretical docking studies and UV titration methods were used for preliminary evaluation of binding of new PAH derivatives to DNA structure. Novel approach to functionalized polycyclic aromatic hydrocarbons (PAHs) is presented. Incorporation of cyclic nitrone framework into the structure of PAHs was studied with respect to their anti-proliferative activities and interaction with double stranded DNA. Theoretical docking studies and UV titration methods were used for preliminary evaluation of binding of new PAH derivatives to DNA structure.
dcterms:title
New PAH derivatives functionalized by cyclic nitrone framework: Synthetic design, anti-proliferative activity and interaction with DNA New PAH derivatives functionalized by cyclic nitrone framework: Synthetic design, anti-proliferative activity and interaction with DNA
skos:prefLabel
New PAH derivatives functionalized by cyclic nitrone framework: Synthetic design, anti-proliferative activity and interaction with DNA New PAH derivatives functionalized by cyclic nitrone framework: Synthetic design, anti-proliferative activity and interaction with DNA
skos:notation
RIV/00216224:14310/13:00066011!RIV14-MSM-14310___
n8:predkladatel
n9:orjk%3A14310
n3:aktivita
n15:S n15:P n15:I
n3:aktivity
I, P(GA203/09/1345), S
n3:cisloPeriodika
5
n3:dodaniDat
n5:2014
n3:domaciTvurceVysledku
n16:9914048 n16:8417377 n16:2333368 n16:9309616
n3:druhVysledku
n10:J
n3:duvernostUdaju
n19:S
n3:entitaPredkladatele
n13:predkladatel
n3:idSjednocenehoVysledku
91643
n3:idVysledku
RIV/00216224:14310/13:00066011
n3:jazykVysledku
n11:eng
n3:klicovaSlova
Polycyclic aromatic hydrocarbon (PAH); Nitrones; DNA; Intercalation; Docking
n3:klicoveSlovo
n6:Polycyclic%20aromatic%20hydrocarbon%20%28PAH%29 n6:Docking n6:Nitrones n6:Intercalation n6:DNA
n3:kodStatuVydavatele
GB - Spojené království Velké Británie a Severního Irska
n3:kontrolniKodProRIV
[4401648AE15D]
n3:nazevZdroje
Bioorganic & Medicinal Chemistry
n3:obor
n17:CC
n3:pocetDomacichTvurcuVysledku
4
n3:pocetTvurcuVysledku
4
n3:projekt
n14:GA203%2F09%2F1345
n3:rokUplatneniVysledku
n5:2013
n3:svazekPeriodika
21
n3:tvurceVysledku
Buchlovič, Marian Hofr, Ctirad Kříž, Zdeněk Potáček, Milan
n3:wos
000314689200005
s:issn
0968-0896
s:numberOfPages
4
n12:doi
10.1016/j.bmc.2013.01.004
n20:organizacniJednotka
14310