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Statements

Subject Item
n2:RIV%2F00216224%3A14310%2F13%3A00065763%21RIV14-MZ0-14310___
rdf:type
n15:Vysledek skos:Concept
dcterms:description
The planar cell polarity (PCP) pathway is a conserved pathway that regulates cell migration and polarity in various contexts. Here we show that key PCP pathway components such as Vangl2, Celsr1, Prickle1, FZD3, FZD7, Dvl2, Dvl3, and casein kinase 1 (CK1)-epsilon are upregulated in B lymphocytes of patients with chronic lymphocytic leukemia (CLL). Elevated levels of PCP proteins accumulate in advanced stages of the disease. Here, we show that PCP pathway is required for the migration and transendothelial invasion of CLL cells and that patients with high expression of PCP genes, FZD3, FZD7, and PRICKLE1, have a less favorable clinical prognosis. Our findings establish that the PCP pathway acts as an important regulator of CLL cell migration and invasion. PCP proteins represent an important class of molecules regulating pathogenic interaction of CLL cells with their microenvironment. The planar cell polarity (PCP) pathway is a conserved pathway that regulates cell migration and polarity in various contexts. Here we show that key PCP pathway components such as Vangl2, Celsr1, Prickle1, FZD3, FZD7, Dvl2, Dvl3, and casein kinase 1 (CK1)-epsilon are upregulated in B lymphocytes of patients with chronic lymphocytic leukemia (CLL). Elevated levels of PCP proteins accumulate in advanced stages of the disease. Here, we show that PCP pathway is required for the migration and transendothelial invasion of CLL cells and that patients with high expression of PCP genes, FZD3, FZD7, and PRICKLE1, have a less favorable clinical prognosis. Our findings establish that the PCP pathway acts as an important regulator of CLL cell migration and invasion. PCP proteins represent an important class of molecules regulating pathogenic interaction of CLL cells with their microenvironment.
dcterms:title
The Planar Cell Polarity Pathway Drives Pathogenesis of Chronic Lymphocytic Leukemia by the Regulation of B-Lymphocyte Migration The Planar Cell Polarity Pathway Drives Pathogenesis of Chronic Lymphocytic Leukemia by the Regulation of B-Lymphocyte Migration
skos:prefLabel
The Planar Cell Polarity Pathway Drives Pathogenesis of Chronic Lymphocytic Leukemia by the Regulation of B-Lymphocyte Migration The Planar Cell Polarity Pathway Drives Pathogenesis of Chronic Lymphocytic Leukemia by the Regulation of B-Lymphocyte Migration
skos:notation
RIV/00216224:14310/13:00065763!RIV14-MZ0-14310___
n15:predkladatel
n20:orjk%3A14310
n3:aktivita
n13:S n13:P n13:I n13:Z
n3:aktivity
I, P(EE2.3.20.0180), P(GAP301/11/0747), P(GAP305/11/0752), P(GD204/09/H058), P(NT11217), P(NT13493), S, Z(MSM0021622430)
n3:cisloPeriodika
5
n3:dodaniDat
n5:2014
n3:domaciTvurceVysledku
n7:3283038 n7:5512646 n7:8054193 n7:5327903 n7:6141994 n7:1957864 n7:3655083 n7:8855803 n7:1721933 n7:5761727 n7:4376285 n7:5802245 n7:1706063 n7:6039146 n7:1248790 n7:7997825
n3:druhVysledku
n9:J
n3:duvernostUdaju
n16:S
n3:entitaPredkladatele
n18:predkladatel
n3:idSjednocenehoVysledku
96343
n3:idVysledku
RIV/00216224:14310/13:00065763
n3:jazykVysledku
n6:eng
n3:klicovaSlova
Planar cell polarity; Wnt; casein kinase 1; B-CLL
n3:klicoveSlovo
n10:Planar%20cell%20polarity n10:Wnt n10:casein%20kinase%201 n10:B-CLL
n3:kodStatuVydavatele
US - Spojené státy americké
n3:kontrolniKodProRIV
[F4B53AF35DF9]
n3:nazevZdroje
Cancer Research
n3:obor
n8:ED
n3:pocetDomacichTvurcuVysledku
16
n3:pocetTvurcuVysledku
17
n3:projekt
n12:GD204%2F09%2FH058 n12:NT13493 n12:EE2.3.20.0180 n12:GAP305%2F11%2F0752 n12:GAP301%2F11%2F0747 n12:NT11217
n3:rokUplatneniVysledku
n5:2013
n3:svazekPeriodika
73
n3:tvurceVysledku
Janovská, Pavlína Kotašková, Jana Pavlová, Šárka Mayer, Jiří Krejčí, Pavel Kozubík, Alois Brychtová, Yvona Ovesná, Petra Procházková, Jiřina Doubek, Michael Shaik, Archana Verner, Jan Bryja, Vítězslav Pospíšilová, Šárka Kaucká, Markéta Tichý, Boris Plevová, Karla
n3:wos
000315741500006
n3:zamer
n19:MSM0021622430
s:issn
0008-5472
s:numberOfPages
11
n17:doi
10.1158/0008-5472.CAN-12-1752
n14:organizacniJednotka
14310