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Statements

Subject Item
n2:RIV%2F00216224%3A14310%2F13%3A00065652%21RIV14-MZ0-14310___
rdf:type
skos:Concept n4:Vysledek
dcterms:description
More than 100 years after description of Alzheimer's disease (AD), two major pathological processes observed already by Alois Alzheimer, remain as the main explanation of the pathogenesis of Alzheimer's disease. Important molecular interactions leading to AD neuropathology were described in amyloid cascade and in tau protein function. No clinical trials with novel therapies based on amyloid cascade and tau protein hypotheses have been successful. The main aim of recent research is focused on the question what is primary mechanism leading to the molecular development of AD pathology. Promising explanation of triggering mechanism can be seen in vascular pathology that have direct influence on the development of pathological processes typical for Alzheimer disease. Novel insight into a number of cellular signaling mechanisms, as well as mitochondrial function in Alzheimer disease could also bring explanations of initial processes leading to the development of this pathology. More than 100 years after description of Alzheimer's disease (AD), two major pathological processes observed already by Alois Alzheimer, remain as the main explanation of the pathogenesis of Alzheimer's disease. Important molecular interactions leading to AD neuropathology were described in amyloid cascade and in tau protein function. No clinical trials with novel therapies based on amyloid cascade and tau protein hypotheses have been successful. The main aim of recent research is focused on the question what is primary mechanism leading to the molecular development of AD pathology. Promising explanation of triggering mechanism can be seen in vascular pathology that have direct influence on the development of pathological processes typical for Alzheimer disease. Novel insight into a number of cellular signaling mechanisms, as well as mitochondrial function in Alzheimer disease could also bring explanations of initial processes leading to the development of this pathology.
dcterms:title
Molecular mechanisms of neuropathological changes in Alzheimer`s disease: a review Molecular mechanisms of neuropathological changes in Alzheimer`s disease: a review
skos:prefLabel
Molecular mechanisms of neuropathological changes in Alzheimer`s disease: a review Molecular mechanisms of neuropathological changes in Alzheimer`s disease: a review
skos:notation
RIV/00216224:14310/13:00065652!RIV14-MZ0-14310___
n4:predkladatel
n5:orjk%3A14310
n6:aktivita
n17:I n17:P
n6:aktivity
I, P(NT11152)
n6:cisloPeriodika
1
n6:dodaniDat
n7:2014
n6:domaciTvurceVysledku
n19:3881652
n6:druhVysledku
n15:J
n6:duvernostUdaju
n12:S
n6:entitaPredkladatele
n14:predkladatel
n6:idSjednocenehoVysledku
89318
n6:idVysledku
RIV/00216224:14310/13:00065652
n6:jazykVysledku
n20:eng
n6:klicovaSlova
Alzheimer`s disease; amyloid precursor protein; tau protein; apolipoprotein E
n6:klicoveSlovo
n8:apolipoprotein%20E n8:tau%20protein n8:Alzheimer%60s%20disease n8:amyloid%20precursor%20protein
n6:kodStatuVydavatele
PL - Polská republika
n6:kontrolniKodProRIV
[38A33B4EAEF5]
n6:nazevZdroje
Folia Neuropathologica
n6:obor
n16:ED
n6:pocetDomacichTvurcuVysledku
1
n6:pocetTvurcuVysledku
5
n6:projekt
n18:NT11152
n6:rokUplatneniVysledku
n7:2013
n6:svazekPeriodika
51
n6:tvurceVysledku
Janout, Vladimír Míšek, Ivan Šerý, Omar Povová, Jana Pešák, Lukáš
n6:wos
000317316400001
s:issn
1641-4640
s:numberOfPages
9
n11:doi
10.5114/fn.2013.34190
n10:organizacniJednotka
14310