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Statements

Subject Item
n2:RIV%2F00216224%3A14310%2F12%3A00060467%21RIV13-MSM-14310___
rdf:type
skos:Concept n15:Vysledek
dcterms:description
The p53 protein is a sequence-specific transcription factor controlling the expression of multiple genes and protecting cells from oncogenic transformation. In many tumors, the p53 protein is completely or partially inactivated by mutations in the p53 gene. We analyzed the transactivating activity of nine human temperature-dependent (td) p53 mutants in yeast cells. Mutations in seven of them were localized in the beta-sandwich-coding region of the p53 gene, eight p53 mutants were temperature-sensitive and the R283C mutant was coldsensitive. Patterns of their transactivation abilities towards three different responsive elements, the extent of their temperature dependency as well as discriminativity, were considerably variable. Similarly, their capacity to become reactivated by amifostine varied from complete resistance to high sensitivity. The p53 protein is a sequence-specific transcription factor controlling the expression of multiple genes and protecting cells from oncogenic transformation. In many tumors, the p53 protein is completely or partially inactivated by mutations in the p53 gene. We analyzed the transactivating activity of nine human temperature-dependent (td) p53 mutants in yeast cells. Mutations in seven of them were localized in the beta-sandwich-coding region of the p53 gene, eight p53 mutants were temperature-sensitive and the R283C mutant was coldsensitive. Patterns of their transactivation abilities towards three different responsive elements, the extent of their temperature dependency as well as discriminativity, were considerably variable. Similarly, their capacity to become reactivated by amifostine varied from complete resistance to high sensitivity.
dcterms:title
Transactivation and reactivation capabilities of temperature-dependent p53 mutants in yeast and human cells Transactivation and reactivation capabilities of temperature-dependent p53 mutants in yeast and human cells
skos:prefLabel
Transactivation and reactivation capabilities of temperature-dependent p53 mutants in yeast and human cells Transactivation and reactivation capabilities of temperature-dependent p53 mutants in yeast and human cells
skos:notation
RIV/00216224:14310/12:00060467!RIV13-MSM-14310___
n15:predkladatel
n16:orjk%3A14310
n4:aktivita
n17:V n17:S n17:P
n4:aktivity
P(NS10448), S, V
n4:cisloPeriodika
3
n4:dodaniDat
n11:2013
n4:domaciTvurceVysledku
n10:1686372 n10:6201431 n10:3295400 n10:6659446
n4:druhVysledku
n19:J
n4:duvernostUdaju
n12:S
n4:entitaPredkladatele
n9:predkladatel
n4:idSjednocenehoVysledku
174840
n4:idVysledku
RIV/00216224:14310/12:00060467
n4:jazykVysledku
n20:eng
n4:klicovaSlova
p53; transactivation; temperature-dependent p53 mutants; discriminating p53 mutants; functional analysis of separated alleles in yeast
n4:klicoveSlovo
n5:p53 n5:functional%20analysis%20of%20separated%20alleles%20in%20yeast n5:discriminating%20p53%20mutants n5:temperature-dependent%20p53%20mutants n5:transactivation
n4:kodStatuVydavatele
GR - Řecká republika
n4:kontrolniKodProRIV
[B4874F0AA4C8]
n4:nazevZdroje
International Journal of Oncology
n4:obor
n14:FD
n4:pocetDomacichTvurcuVysledku
4
n4:pocetTvurcuVysledku
6
n4:projekt
n18:NS10448
n4:rokUplatneniVysledku
n11:2012
n4:svazekPeriodika
41
n4:tvurceVysledku
Slováčková, Jana Šmardová, Jana Šmarda, Jan Pitrová, Lenka Jagošová, Jana Ravčuková, Barbora
n4:wos
000307150000042
s:issn
1019-6439
s:numberOfPages
7
n7:doi
10.3892/ijo.2012.1520
n6:organizacniJednotka
14310