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Statements

Subject Item
n2:RIV%2F00216224%3A14310%2F12%3A00060443%21RIV13-MSM-14310___
rdf:type
n4:Vysledek skos:Concept
dcterms:description
Mycobacterium tuberculosis is a gram positive, acid resistent bacterium causing chronic illness. Tuberculosis is characterized by a disease persistence and overall difficulties associated with its treatment. A combination of the sophisticated defence barrier and the slow metabolism of the bacterium make it a difficult target for therapeutics. The mycobacterial cell wall is an essential, covalently linked complex of highly hydrophobic mycolic acids, peptidoglycan and heteropolymeric arabinogalactan. Arabinogalactan is composed of about 30 alternating 5- and 6-linked b-D-galactofuranose (Galf) units. It anchores in peptidoglycan by a dedicated linker unit, a-L-rhamnopyranosyl-(1-3)-N-acetyl-a-D-glucosaminyl-phosphate [Rha-(1-3)-GlcNAc-P]. Two to three arabinan chains containing approximately 23 D-arabinofuranose (Araf) units each, composed mostly of 5-linked a-D-Araf with branching introduced by 3,5-a-D-Araf, are bound to the galactan. Mycobacterium tuberculosis is a gram positive, acid resistent bacterium causing chronic illness. Tuberculosis is characterized by a disease persistence and overall difficulties associated with its treatment. A combination of the sophisticated defence barrier and the slow metabolism of the bacterium make it a difficult target for therapeutics. The mycobacterial cell wall is an essential, covalently linked complex of highly hydrophobic mycolic acids, peptidoglycan and heteropolymeric arabinogalactan. Arabinogalactan is composed of about 30 alternating 5- and 6-linked b-D-galactofuranose (Galf) units. It anchores in peptidoglycan by a dedicated linker unit, a-L-rhamnopyranosyl-(1-3)-N-acetyl-a-D-glucosaminyl-phosphate [Rha-(1-3)-GlcNAc-P]. Two to three arabinan chains containing approximately 23 D-arabinofuranose (Araf) units each, composed mostly of 5-linked a-D-Araf with branching introduced by 3,5-a-D-Araf, are bound to the galactan.
dcterms:title
Expression of mycobacterial Rv3782 galactofuranosyltransferase in fussion with MBP Expression of mycobacterial Rv3782 galactofuranosyltransferase in fussion with MBP
skos:prefLabel
Expression of mycobacterial Rv3782 galactofuranosyltransferase in fussion with MBP Expression of mycobacterial Rv3782 galactofuranosyltransferase in fussion with MBP
skos:notation
RIV/00216224:14310/12:00060443!RIV13-MSM-14310___
n4:predkladatel
n16:orjk%3A14310
n3:aktivita
n7:S
n3:aktivity
S
n3:dodaniDat
n14:2013
n3:domaciTvurceVysledku
n6:5522064 n6:7374062 n6:6129005 n6:4177762
n3:druhVysledku
n5:O
n3:duvernostUdaju
n13:S
n3:entitaPredkladatele
n8:predkladatel
n3:idSjednocenehoVysledku
135885
n3:idVysledku
RIV/00216224:14310/12:00060443
n3:jazykVysledku
n17:eng
n3:klicovaSlova
cell wall; glycosyltransferase; galactofuranosyltransferase; Mycobacterium tuberculosis; protein expression; protein purification; tuberculosis
n3:klicoveSlovo
n9:cell%20wall n9:glycosyltransferase n9:protein%20expression n9:protein%20purification n9:tuberculosis n9:galactofuranosyltransferase n9:Mycobacterium%20tuberculosis
n3:kontrolniKodProRIV
[80F7674A183A]
n3:obor
n12:CE
n3:pocetDomacichTvurcuVysledku
4
n3:pocetTvurcuVysledku
4
n3:rokUplatneniVysledku
n14:2012
n3:tvurceVysledku
Rotková, Gabriela Kyseľ, Peter Wimmerová, Michaela Kostlánová, Nikola
n15:organizacniJednotka
14310