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Statements

Subject Item
n2:RIV%2F00216224%3A14310%2F12%3A00060103%21RIV13-MSM-14310___
rdf:type
n16:Vysledek skos:Concept
dcterms:description
Metal complexes of fungal and plant secondary metabolites are in the centre of interest, especially due to their biological properties including cytotoxicity. In our work, we were focused on electrochemical behaviour of seven newly prepared complexes of lawsone with the second ligand represented by derivatives of pyridine, aminopyridine and pyrazole with copper(II) ions using methods of cyclic voltammetry and differential pulse voltammetry. In addition, we tested ability of these complexes to interact with DNA. Our results indicate that the most simple complex of lawsone - Cu(lawsone)2(H2O)20.5H2O proved significant prooxidant properties, which may contribute to its cytotoxicity that has been demonstrated in recent literature. Metal complexes of fungal and plant secondary metabolites are in the centre of interest, especially due to their biological properties including cytotoxicity. In our work, we were focused on electrochemical behaviour of seven newly prepared complexes of lawsone with the second ligand represented by derivatives of pyridine, aminopyridine and pyrazole with copper(II) ions using methods of cyclic voltammetry and differential pulse voltammetry. In addition, we tested ability of these complexes to interact with DNA. Our results indicate that the most simple complex of lawsone - Cu(lawsone)2(H2O)20.5H2O proved significant prooxidant properties, which may contribute to its cytotoxicity that has been demonstrated in recent literature.
dcterms:title
VOLTAMMETRY OF LAWSONE- COPPER(II)-DNA COMPLEXES VOLTAMMETRY OF LAWSONE- COPPER(II)-DNA COMPLEXES
skos:prefLabel
VOLTAMMETRY OF LAWSONE- COPPER(II)-DNA COMPLEXES VOLTAMMETRY OF LAWSONE- COPPER(II)-DNA COMPLEXES
skos:notation
RIV/00216224:14310/12:00060103!RIV13-MSM-14310___
n16:predkladatel
n17:orjk%3A14310
n3:aktivita
n15:I
n3:aktivity
I
n3:dodaniDat
n12:2013
n3:domaciTvurceVysledku
n7:3790185
n3:druhVysledku
n18:D
n3:duvernostUdaju
n13:S
n3:entitaPredkladatele
n5:predkladatel
n3:idSjednocenehoVysledku
178556
n3:idVysledku
RIV/00216224:14310/12:00060103
n3:jazykVysledku
n20:eng
n3:klicovaSlova
metal complexes; cytotoxicity; copper; pyridine; aminopyridine; pyrazole; cyclic voltammetry; diferential pulse voltammetry; DNA
n3:klicoveSlovo
n4:diferential%20pulse%20voltammetry n4:metal%20complexes n4:cyclic%20voltammetry n4:cytotoxicity n4:pyridine n4:DNA n4:copper n4:pyrazole n4:aminopyridine
n3:kontrolniKodProRIV
[6E3E9A6F6E73]
n3:mistoKonaniAkce
Brno
n3:mistoVydani
Brno
n3:nazevZdroje
XII. Pracovní setkání fyzikálních chemiků a elektrochemiků. Sborník příspěvků.
n3:obor
n19:CF
n3:pocetDomacichTvurcuVysledku
1
n3:pocetTvurcuVysledku
9
n3:rokUplatneniVysledku
n12:2012
n3:tvurceVysledku
Kizek, René Sochor, Jiří Hubálek, Jaromír Krejčová, Ludmila Hynek, David Trnková, Libuše Adam, Vojtěch Vančo, Jan Babula, Petr
n3:typAkce
n21:EUR
n3:zahajeniAkce
2012-01-01+01:00
s:numberOfPages
3
n11:hasPublisher
Mendelova zemědělská a lesnická univerzita v Brně
n9:isbn
9788073756185
n6:organizacniJednotka
14310