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Statements

Subject Item
n2:RIV%2F00216224%3A14310%2F12%3A00058218%21RIV13-GA0-14310___
rdf:type
n8:Vysledek skos:Concept
dcterms:description
Apicomplexans represent one of the most successful and diverse group of unicellular parasites exhibiting unique adaptations to their life style. Many of them are causative agents for major human diseases (such as malaria, toxoplasmosis and cryptosporidiosis), which are still poorly controlled and require development of novel sustainable therapies. The apicomplexan cytoskeletal elements play an important role in various life processes and thus they represent a potential target for chemotherapeutic intervention. Their highly motile invasive zoites use a unique conserved form of actin-based gliding motility for movement, host cell invasion and tissue traversal. Our intent is to investigate if the glideosome concept, proposed in Toxoplasma, could be also applied to basal lineages of Apicomplexa. We focus on deep-branching groups, especially gregarines and protococcidians, restricted to invertebrates (Diakin et al. 2012). Apicomplexans represent one of the most successful and diverse group of unicellular parasites exhibiting unique adaptations to their life style. Many of them are causative agents for major human diseases (such as malaria, toxoplasmosis and cryptosporidiosis), which are still poorly controlled and require development of novel sustainable therapies. The apicomplexan cytoskeletal elements play an important role in various life processes and thus they represent a potential target for chemotherapeutic intervention. Their highly motile invasive zoites use a unique conserved form of actin-based gliding motility for movement, host cell invasion and tissue traversal. Our intent is to investigate if the glideosome concept, proposed in Toxoplasma, could be also applied to basal lineages of Apicomplexa. We focus on deep-branching groups, especially gregarines and protococcidians, restricted to invertebrates (Diakin et al. 2012).
dcterms:title
Cell motility in marine early emerging apicomplexans Cell motility in marine early emerging apicomplexans
skos:prefLabel
Cell motility in marine early emerging apicomplexans Cell motility in marine early emerging apicomplexans
skos:notation
RIV/00216224:14310/12:00058218!RIV13-GA0-14310___
n8:predkladatel
n9:orjk%3A14310
n3:aktivita
n17:P
n3:aktivity
P(GBP505/12/G112)
n3:dodaniDat
n16:2013
n3:domaciTvurceVysledku
n6:7951302
n3:druhVysledku
n5:O
n3:duvernostUdaju
n14:S
n3:entitaPredkladatele
n11:predkladatel
n3:idSjednocenehoVysledku
126224
n3:idVysledku
RIV/00216224:14310/12:00058218
n3:jazykVysledku
n7:eng
n3:klicovaSlova
apicomplexa; gregarines; cell motility; cortex; pellicle; actin; myosin; marine
n3:klicoveSlovo
n4:apicomplexa n4:gregarines n4:cell%20motility n4:actin n4:pellicle n4:myosin n4:cortex n4:marine
n3:kontrolniKodProRIV
[70B1B4F6D8EF]
n3:obor
n15:EG
n3:pocetDomacichTvurcuVysledku
1
n3:pocetTvurcuVysledku
4
n3:projekt
n10:GBP505%2F12%2FG112
n3:rokUplatneniVysledku
n16:2012
n3:tvurceVysledku
Valigurová, Andrea Simdyanov, Timur G. Diakin, Andrei Schrevel, Joseph
n18:organizacniJednotka
14310