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Statements

Subject Item
n2:RIV%2F00216224%3A14310%2F11%3A00053414%21RIV12-MSM-14310___
rdf:type
n3:Vysledek skos:Concept
dcterms:description
This study investigated PAHs and N-PAHs interference with retinoid signaling in vitro by modulating all-trans retinoic acid (ATRA) mediated response in a reporter gene assay using P19/A15 cell line. Further, effects on pluripotency and differentiation processes were evaluated by measuring octamer-4 (Oct-4), an important pluripotency marker and master differentiation factor. Our results further extend the knowledge of PAH and N-PAH in vitro effects and indicate that these environmental toxicants may have influence on differentiation process and embryonic development by interfering with ATRA signaling and by modulating levels of Oct-4. This study investigated PAHs and N-PAHs interference with retinoid signaling in vitro by modulating all-trans retinoic acid (ATRA) mediated response in a reporter gene assay using P19/A15 cell line. Further, effects on pluripotency and differentiation processes were evaluated by measuring octamer-4 (Oct-4), an important pluripotency marker and master differentiation factor. Our results further extend the knowledge of PAH and N-PAH in vitro effects and indicate that these environmental toxicants may have influence on differentiation process and embryonic development by interfering with ATRA signaling and by modulating levels of Oct-4.
dcterms:title
The effects of PAHs and N-PAHs on retinoid signalling and Oct-4 expression in vitro. The effects of PAHs and N-PAHs on retinoid signalling and Oct-4 expression in vitro.
skos:prefLabel
The effects of PAHs and N-PAHs on retinoid signalling and Oct-4 expression in vitro. The effects of PAHs and N-PAHs on retinoid signalling and Oct-4 expression in vitro.
skos:notation
RIV/00216224:14310/11:00053414!RIV12-MSM-14310___
n3:predkladatel
n10:orjk%3A14310
n4:aktivita
n15:S n15:P n15:Z
n4:aktivity
P(2B08036), P(ED0001/01/01), S, Z(MSM0021622412)
n4:cisloPeriodika
3
n4:dodaniDat
n13:2012
n4:domaciTvurceVysledku
n12:3738582 n12:4982800 n12:9372318 n12:6075878
n4:druhVysledku
n17:J
n4:duvernostUdaju
n19:S
n4:entitaPredkladatele
n18:predkladatel
n4:idSjednocenehoVysledku
196661
n4:idVysledku
RIV/00216224:14310/11:00053414
n4:jazykVysledku
n5:eng
n4:klicovaSlova
retinoids; differentiation; Oct-4; PAHs; N-PAHs
n4:klicoveSlovo
n14:retinoids n14:differentiation n14:PAHs n14:Oct-4 n14:N-PAHs
n4:kodStatuVydavatele
IE - Irsko
n4:kontrolniKodProRIV
[6EE28084D683]
n4:nazevZdroje
Toxicology Letters
n4:obor
n20:DN
n4:pocetDomacichTvurcuVysledku
4
n4:pocetTvurcuVysledku
4
n4:projekt
n11:2B08036 n11:ED0001%2F01%2F01
n4:rokUplatneniVysledku
n13:2011
n4:svazekPeriodika
200
n4:tvurceVysledku
Beníšek, Martin Hilscherová, Klára Kubincová, Petra Bláha, Luděk
n4:wos
000287216900006
n4:zamer
n21:MSM0021622412
s:issn
0378-4274
s:numberOfPages
7
n6:doi
10.1016/j.toxlet.2010.11.011
n7:organizacniJednotka
14310