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Statements

Subject Item
n2:RIV%2F00216224%3A14310%2F11%3A00049487%21RIV12-GA0-14310___
rdf:type
skos:Concept n13:Vysledek
dcterms:description
Breast cancer cells overexpressing cathepsin D wt and mut were exposed to TRAIL and frequency of apoptosis was determined by chromatin condensation, nuclear fragmentation, cleavage of PARP, and externalization of phosphatidylserine. An increased frequency of apoptosis in cells over-expressing wt but not mut CTSD was clearly demonstrated. Increased frequency of apoptosis observed in wt CTSD cells corresponded to cleavage of the pro-apoptotic Bcl-2 family member, the Bid protein, that was earlier identified as one of the targets of CTSD in cancer cells. We conclude that CTSD sensitizes MDA-MB-231 cells to the TRAIL-induced apoptosis in enzymatic activity-dependent manner and that the TRAIL-induced apoptosis is potentiated by the CTSD-mediated activation of Bid, the pro-apoptotic member of the Bcl-2 family. Breast cancer cells overexpressing cathepsin D wt and mut were exposed to TRAIL and frequency of apoptosis was determined by chromatin condensation, nuclear fragmentation, cleavage of PARP, and externalization of phosphatidylserine. An increased frequency of apoptosis in cells over-expressing wt but not mut CTSD was clearly demonstrated. Increased frequency of apoptosis observed in wt CTSD cells corresponded to cleavage of the pro-apoptotic Bcl-2 family member, the Bid protein, that was earlier identified as one of the targets of CTSD in cancer cells. We conclude that CTSD sensitizes MDA-MB-231 cells to the TRAIL-induced apoptosis in enzymatic activity-dependent manner and that the TRAIL-induced apoptosis is potentiated by the CTSD-mediated activation of Bid, the pro-apoptotic member of the Bcl-2 family.
dcterms:title
OVEREXPRESSION OF CATHEPSIN D SENZITIZES BREAST CANCER CELLS TO TRAIL-INDUCED APOPTOSIS OVEREXPRESSION OF CATHEPSIN D SENZITIZES BREAST CANCER CELLS TO TRAIL-INDUCED APOPTOSIS
skos:prefLabel
OVEREXPRESSION OF CATHEPSIN D SENZITIZES BREAST CANCER CELLS TO TRAIL-INDUCED APOPTOSIS OVEREXPRESSION OF CATHEPSIN D SENZITIZES BREAST CANCER CELLS TO TRAIL-INDUCED APOPTOSIS
skos:notation
RIV/00216224:14310/11:00049487!RIV12-GA0-14310___
n13:predkladatel
n16:orjk%3A14310
n3:aktivita
n5:P n5:Z
n3:aktivity
P(GA301/09/1115), P(GD204/08/H054), P(IAA501630801), Z(MSM0021622415)
n3:dodaniDat
n14:2012
n3:domaciTvurceVysledku
n10:5687683 n10:6659446
n3:druhVysledku
n9:O
n3:duvernostUdaju
n18:S
n3:entitaPredkladatele
n6:predkladatel
n3:idSjednocenehoVysledku
219224
n3:idVysledku
RIV/00216224:14310/11:00049487
n3:jazykVysledku
n12:eng
n3:klicovaSlova
apoptosis; TRAIL; cathepsin D; breast cancer
n3:klicoveSlovo
n15:TRAIL n15:cathepsin%20D n15:apoptosis n15:breast%20cancer
n3:kontrolniKodProRIV
[2FD78F99C910]
n3:obor
n4:EB
n3:pocetDomacichTvurcuVysledku
2
n3:pocetTvurcuVysledku
4
n3:projekt
n8:IAA501630801 n8:GD204%2F08%2FH054 n8:GA301%2F09%2F1115
n3:rokUplatneniVysledku
n14:2011
n3:tvurceVysledku
Ondroušková, Eva Beneš, Petr Šmarda, Jan Jančeková, Blanka
n3:zamer
n17:MSM0021622415
n19:organizacniJednotka
14310