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Statements

Subject Item
n2:RIV%2F00216224%3A14310%2F10%3A00044943%21RIV11-MSM-14310___
rdf:type
skos:Concept n12:Vysledek
dcterms:description
Glyoxyl analogs of indole phytoalexins brassinin, 1-methoxybrassinin, brassitin, 1-methoxybrassitin and 1-methoxybrassenin B were prepared, using (1H-indol-3-yl)-, (1-methoxyindol- 3-yl)- and [1-(2,3,4,6-tetra-O-acetyl-beta-D-glucopyranosyl)indol-3-yl]glyoxyl chlorides as starting compounds. Synthesized products were examined for their antiproliferative activity against human cancer cell lines Jurkat (T-cell acute lymphoblastic leukemia), MCF-7 (breast adenocarcinoma, estrogen receptor-positive), MDA-MB-231 (breast adenocarcinoma, estrogen receptor-negative), HeLa (cervical adenocarcinoma), CCRF-CEM cell line (T-cell acute lymphoblastic leukemia) and A-549 cell line (lung adenocarcinoma), and their activity compared with natural phytoalexins and corresponding (1H-indol-3-yl)acetic acid derivatives. The highest potency with IC50 3.3-66.1 mímol l-1 was found for glyoxyl analogs of 1-methoxybrassenin B. Glyoxyl analogs of indole phytoalexins brassinin, 1-methoxybrassinin, brassitin, 1-methoxybrassitin and 1-methoxybrassenin B were prepared, using (1H-indol-3-yl)-, (1-methoxyindol- 3-yl)- and [1-(2,3,4,6-tetra-O-acetyl-beta-D-glucopyranosyl)indol-3-yl]glyoxyl chlorides as starting compounds. Synthesized products were examined for their antiproliferative activity against human cancer cell lines Jurkat (T-cell acute lymphoblastic leukemia), MCF-7 (breast adenocarcinoma, estrogen receptor-positive), MDA-MB-231 (breast adenocarcinoma, estrogen receptor-negative), HeLa (cervical adenocarcinoma), CCRF-CEM cell line (T-cell acute lymphoblastic leukemia) and A-549 cell line (lung adenocarcinoma), and their activity compared with natural phytoalexins and corresponding (1H-indol-3-yl)acetic acid derivatives. The highest potency with IC50 3.3-66.1 mímol l-1 was found for glyoxyl analogs of 1-methoxybrassenin B.
dcterms:title
GLYOXYL ANALOGS OF INDOLE PHYTOALEXINS: SYNTHESIS AND ANTICANCER ACTIVITY GLYOXYL ANALOGS OF INDOLE PHYTOALEXINS: SYNTHESIS AND ANTICANCER ACTIVITY
skos:prefLabel
GLYOXYL ANALOGS OF INDOLE PHYTOALEXINS: SYNTHESIS AND ANTICANCER ACTIVITY GLYOXYL ANALOGS OF INDOLE PHYTOALEXINS: SYNTHESIS AND ANTICANCER ACTIVITY
skos:notation
RIV/00216224:14310/10:00044943!RIV11-MSM-14310___
n3:aktivita
n17:S
n3:aktivity
S
n3:cisloPeriodika
8
n3:dodaniDat
n9:2011
n3:domaciTvurceVysledku
n10:9756078
n3:druhVysledku
n15:J
n3:duvernostUdaju
n11:S
n3:entitaPredkladatele
n7:predkladatel
n3:idSjednocenehoVysledku
260857
n3:idVysledku
RIV/00216224:14310/10:00044943
n3:jazykVysledku
n13:eng
n3:klicovaSlova
Heterocycles; Indoles; Natural products; Phytoalexins; Glyoxylindoles
n3:klicoveSlovo
n4:Indoles n4:Heterocycles n4:Glyoxylindoles n4:Phytoalexins n4:Natural%20products
n3:kodStatuVydavatele
CZ - Česká republika
n3:kontrolniKodProRIV
[384DB899CC29]
n3:nazevZdroje
Collection of Czechoslovak Chemical Communications
n3:obor
n14:CC
n3:pocetDomacichTvurcuVysledku
1
n3:pocetTvurcuVysledku
9
n3:rokUplatneniVysledku
n9:2010
n3:svazekPeriodika
75
n3:tvurceVysledku
Kutschy, Peter Hromjáková, Tatiana Čurillová, Zuzana Pilátová, Martina Sýkora, Andrej Pazdera, Pavel Mojžiš, Ján Mezencev, Roman Repovská, Mária
n3:wos
2010048
s:issn
0010-0765
s:numberOfPages
12
n16:organizacniJednotka
14310