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Statements

Subject Item
n2:RIV%2F00216224%3A14310%2F10%3A00042665%21RIV11-GA0-14310___
rdf:type
skos:Concept n15:Vysledek
dcterms:description
The pyridinium oxime therapy for treatment of organophosphate poisoning is a well established, but not sufficient method. Recent trends also focus on prophylaxis as a way of preventing even the entrance of organophosphates into the nervous system. One of the possible prophylactic methods is increasing the concentration of butyrylcholinesterase in blood with the simultaneous administration of butyrylcholinesterase reactivators, when the enzyme is continuously reactivated by oxime. This article summarises and sets forth the structural differences between butyrylcholinesterase and acetylcholinesterase essential for future design of butyrylcholinesterase reactivators. Butyrylcholinesterase lacks the reactivator aromatic binding pocket found in acetylcholinesterase, which is itself a part of the acetylcholinesterase peripheral anionic site. This difference finally renders the current acetylcholinesterase reactivators, while used in butyrylcholinesterase, non-functional. The pyridinium oxime therapy for treatment of organophosphate poisoning is a well established, but not sufficient method. Recent trends also focus on prophylaxis as a way of preventing even the entrance of organophosphates into the nervous system. One of the possible prophylactic methods is increasing the concentration of butyrylcholinesterase in blood with the simultaneous administration of butyrylcholinesterase reactivators, when the enzyme is continuously reactivated by oxime. This article summarises and sets forth the structural differences between butyrylcholinesterase and acetylcholinesterase essential for future design of butyrylcholinesterase reactivators. Butyrylcholinesterase lacks the reactivator aromatic binding pocket found in acetylcholinesterase, which is itself a part of the acetylcholinesterase peripheral anionic site. This difference finally renders the current acetylcholinesterase reactivators, while used in butyrylcholinesterase, non-functional.
dcterms:title
Why acetylcholinesterase reactivators do not work in butyrylcholinesterase Why acetylcholinesterase reactivators do not work in butyrylcholinesterase
skos:prefLabel
Why acetylcholinesterase reactivators do not work in butyrylcholinesterase Why acetylcholinesterase reactivators do not work in butyrylcholinesterase
skos:notation
RIV/00216224:14310/10:00042665!RIV11-GA0-14310___
n4:aktivita
n13:Z n13:S n13:P
n4:aktivity
P(GD204/03/H016), P(LC06030), S, Z(MSM0021622413)
n4:cisloPeriodika
3
n4:dodaniDat
n6:2011
n4:domaciTvurceVysledku
n8:9309616 n8:4347374 n8:9762132
n4:druhVysledku
n18:J
n4:duvernostUdaju
n12:S
n4:entitaPredkladatele
n10:predkladatel
n4:idSjednocenehoVysledku
298797
n4:idVysledku
RIV/00216224:14310/10:00042665
n4:jazykVysledku
n17:eng
n4:klicovaSlova
butyrylcholinesterase; acetylcholinesterase; reactivation; pyridinium oximes; reactivator aromatic binding pocket; peripheral anionic site
n4:klicoveSlovo
n5:butyrylcholinesterase n5:peripheral%20anionic%20site n5:reactivation n5:acetylcholinesterase n5:reactivator%20aromatic%20binding%20pocket n5:pyridinium%20oximes
n4:kodStatuVydavatele
CZ - Česká republika
n4:kontrolniKodProRIV
[30119D945197]
n4:nazevZdroje
Journal of Enzyme Inhibition and Medicinal Chemistry
n4:obor
n7:CF
n4:pocetDomacichTvurcuVysledku
3
n4:pocetTvurcuVysledku
5
n4:projekt
n14:LC06030 n14:GD204%2F03%2FH016
n4:rokUplatneniVysledku
n6:2010
n4:svazekPeriodika
25
n4:tvurceVysledku
Kuča, Kamil Kříž, Zdeněk Koča, Jaroslav Jun, Daniel Wiesner, Jiří
n4:zamer
n19:MSM0021622413
s:issn
1475-6366
s:numberOfPages
5
n16:organizacniJednotka
14310