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Statements

Subject Item
n2:RIV%2F00216224%3A14310%2F10%3A00040623%21RIV11-GA0-14310___
rdf:type
n6:Vysledek skos:Concept
dcterms:description
Sequence-dependent recognition of dsDNA-binding proteins is well understood, yet sequence-specific recognition of dsRNA by proteins remains largely unknown, despite their importance in RNA maturation pathways. Adenosine deaminases that act on RNA (ADARs) recode genomic information by the site-selective deamination of adenosine. Here, we report the solution structure of the ADAR2 double-stranded RNA-binding motifs (dsRBMs) bound to a stem-loop pre-mRNA encoding the R/G editing site of GluR-2. The structure provides a molecular basis for how dsRBMs recognize the shape, and also more surprisingly, the sequence of the dsRNA. The unexpected direct readout of the RNA primary sequence by dsRBMs is achieved via the minor groove of the dsRNA and this recognition is critical for both editing and binding affinity at the R/G site of GluR-2. Sequence-dependent recognition of dsDNA-binding proteins is well understood, yet sequence-specific recognition of dsRNA by proteins remains largely unknown, despite their importance in RNA maturation pathways. Adenosine deaminases that act on RNA (ADARs) recode genomic information by the site-selective deamination of adenosine. Here, we report the solution structure of the ADAR2 double-stranded RNA-binding motifs (dsRBMs) bound to a stem-loop pre-mRNA encoding the R/G editing site of GluR-2. The structure provides a molecular basis for how dsRBMs recognize the shape, and also more surprisingly, the sequence of the dsRNA. The unexpected direct readout of the RNA primary sequence by dsRBMs is achieved via the minor groove of the dsRNA and this recognition is critical for both editing and binding affinity at the R/G site of GluR-2.
dcterms:title
The Solution Structure of the ADAR2 dsRBM-RNA Complex Reveals a Sequence-Specific Readout of the Minor Groove The Solution Structure of the ADAR2 dsRBM-RNA Complex Reveals a Sequence-Specific Readout of the Minor Groove
skos:prefLabel
The Solution Structure of the ADAR2 dsRBM-RNA Complex Reveals a Sequence-Specific Readout of the Minor Groove The Solution Structure of the ADAR2 dsRBM-RNA Complex Reveals a Sequence-Specific Readout of the Minor Groove
skos:notation
RIV/00216224:14310/10:00040623!RIV11-GA0-14310___
n3:aktivita
n16:P n16:Z
n3:aktivity
P(GA204/08/1212), P(GAP305/10/1490), P(GD204/08/H054), P(IAA401630903), P(LA08008), Z(MSM0021622413), Z(MSM0021622415)
n3:cisloPeriodika
2
n3:dodaniDat
n9:2011
n3:domaciTvurceVysledku
n14:4123468 n14:6439608 n14:9914048 n14:9928758 Allain, Frederic
n3:druhVysledku
n13:J
n3:duvernostUdaju
n18:S
n3:entitaPredkladatele
n17:predkladatel
n3:idSjednocenehoVysledku
288534
n3:idVysledku
RIV/00216224:14310/10:00040623
n3:jazykVysledku
n10:eng
n3:klicovaSlova
OUBLE-STRANDED-RNA; TORSION ANGLE DYNAMICS; DSRNA-BINDING DOMAIN; ADENOSINE DEAMINASES; RIBONUCLEASE-III; EDITING ENZYME; PROTEIN-KINASE; GLUR-B; NMR; RECOGNITION
n3:klicoveSlovo
n5:ADENOSINE%20DEAMINASES n5:GLUR-B n5:DSRNA-BINDING%20DOMAIN n5:PROTEIN-KINASE n5:RIBONUCLEASE-III n5:RECOGNITION n5:OUBLE-STRANDED-RNA n5:TORSION%20ANGLE%20DYNAMICS n5:NMR n5:EDITING%20ENZYME
n3:kodStatuVydavatele
US - Spojené státy americké
n3:kontrolniKodProRIV
[7CAC1A853CAB]
n3:nazevZdroje
CELL
n3:obor
n19:CE
n3:pocetDomacichTvurcuVysledku
5
n3:pocetTvurcuVysledku
11
n3:projekt
n4:IAA401630903 n4:GD204%2F08%2FH054 n4:GA204%2F08%2F1212 n4:LA08008 n4:GAP305%2F10%2F1490
n3:rokUplatneniVysledku
n9:2010
n3:svazekPeriodika
143
n3:tvurceVysledku
Hofr, Ctirad Štefl, Richard Peng, Li Hood, Jeniffer Skříšovská, Lenka Maris, Christophe Zimmermann, Michal Emeson, Ronald Jourdan, Muriel Allain, Frederic Oberstrass, Florian
n3:wos
000283052200012
n3:zamer
n12:MSM0021622415 n12:MSM0021622413
s:issn
0092-8674
s:numberOfPages
13
n7:organizacniJednotka
14310