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Statements

Subject Item
n2:RIV%2F00216224%3A14310%2F09%3A00037268%21RIV10-MSM-14310___
rdf:type
n6:Vysledek skos:Concept
dcterms:description
Multiform glioblastoma (GBM) is by far the most malignant form of primary brain tumors with limited therapeutic options. Median survival is estimated approximately to 12 months with less than 25% of patients surviving up to 2 years after diagnosis and less than 10% surviving up to 5 years. Despite great efforts, standard therapy based on neurosurgery, chemo- and radiotherapy fails. GBM tumors often avoid immune surveillance by inhibition of infiltrating immune cells by paracrine signaling. Among these factors, proteins of TGFb family are highly involved. In this study, we focused on expression of TGFbeta1-3, BMP-7, BMP-9, GDF-15 and other growth factors, immunomodulators or tumor-associated genes in samples of patients newly diagnosed for GBM. These samples were analyzed by quantitative PCR and normalized either to control, healthy brain tissue, or non-malignant disease. We found significant change of expression several genes of TGFbeta family that correlates with development of malignant disease. Multiform glioblastoma (GBM) is by far the most malignant form of primary brain tumors with limited therapeutic options. Median survival is estimated approximately to 12 months with less than 25% of patients surviving up to 2 years after diagnosis and less than 10% surviving up to 5 years. Despite great efforts, standard therapy based on neurosurgery, chemo- and radiotherapy fails. GBM tumors often avoid immune surveillance by inhibition of infiltrating immune cells by paracrine signaling. Among these factors, proteins of TGFb family are highly involved. In this study, we focused on expression of TGFbeta1-3, BMP-7, BMP-9, GDF-15 and other growth factors, immunomodulators or tumor-associated genes in samples of patients newly diagnosed for GBM. These samples were analyzed by quantitative PCR and normalized either to control, healthy brain tissue, or non-malignant disease. We found significant change of expression several genes of TGFbeta family that correlates with development of malignant disease.
dcterms:title
Monitoring of immunosuppressive cytokines in glioblastoma Monitoring of immunosuppressive cytokines in glioblastoma
skos:prefLabel
Monitoring of immunosuppressive cytokines in glioblastoma Monitoring of immunosuppressive cytokines in glioblastoma
skos:notation
RIV/00216224:14310/09:00037268!RIV10-MSM-14310___
n3:aktivita
n11:Z
n3:aktivity
Z(MSM0021622415)
n3:dodaniDat
n17:2010
n3:domaciTvurceVysledku
n4:6723381 n4:8761078 n4:6522319 n4:8075956 n4:1703722 n4:6659446 n4:5132606 n4:7248857
n3:druhVysledku
n15:O
n3:duvernostUdaju
n10:S
n3:entitaPredkladatele
n13:predkladatel
n3:idSjednocenehoVysledku
327329
n3:idVysledku
RIV/00216224:14310/09:00037268
n3:jazykVysledku
n16:eng
n3:klicovaSlova
glioblastoma; immunosuppresion; TGFbeta; qRT-PCR
n3:klicoveSlovo
n5:glioblastoma n5:immunosuppresion n5:qRT-PCR n5:TGFbeta
n3:kontrolniKodProRIV
[F5F859BAB020]
n3:obor
n14:FD
n3:pocetDomacichTvurcuVysledku
8
n3:pocetTvurcuVysledku
8
n3:rokUplatneniVysledku
n17:2009
n3:tvurceVysledku
Vaňhara, Petr Křen, Leoš Šmejkal, Jiří Šmarda, Jan Michálek, Jaroslav Sova, Marek Smrčka, Martin Ševčíková, Sabina
n3:zamer
n12:MSM0021622415
n7:organizacniJednotka
14310