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Statements

Subject Item
n2:RIV%2F00216224%3A14310%2F09%3A00029898%21RIV10-MSM-14310___
rdf:type
skos:Concept n16:Vysledek
dcterms:description
Humic substances (HS) are ubiquitous natural products of decomposition of dead organic matter. HS is present in most freshwaters at concentrations ranging from 0.5 to 50 mg L-1. Organic carbon can represent 20% dry weight of sediments. Recently, the interaction of dissolved HS with the aryl hydrocarbon receptor (AhR) has been demonstrated. The AhR is a cytosolic receptor to which persistent organic pollutants (POPs) can bind and many of their toxic effects are mediated through interactions with this receptor. We describe in vitro effects (using H4IIE-luc cells) of binary mixtures of various HS with 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), since in contaminated environments these compounds occur simultaneously. Six out of 12 HS samples activated AhR even at environmentally relevant concentrations (17 mg L-1), but did not reach the full AhR-activation even at excessive concentration. In simultaneous exposure of H4IIE-luc to HS (17 mg L-1) and TCDD (1. Humic substances (HS) are ubiquitous natural products of decomposition of dead organic matter. HS is present in most freshwaters at concentrations ranging from 0.5 to 50 mg L-1. Organic carbon can represent 20% dry weight of sediments. Recently, the interaction of dissolved HS with the aryl hydrocarbon receptor (AhR) has been demonstrated. The AhR is a cytosolic receptor to which persistent organic pollutants (POPs) can bind and many of their toxic effects are mediated through interactions with this receptor. We describe in vitro effects (using H4IIE-luc cells) of binary mixtures of various HS with 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), since in contaminated environments these compounds occur simultaneously. Six out of 12 HS samples activated AhR even at environmentally relevant concentrations (17 mg L-1), but did not reach the full AhR-activation even at excessive concentration. In simultaneous exposure of H4IIE-luc to HS (17 mg L-1) and TCDD (1.
dcterms:title
In vitro assessment of AhR-mediated activities of TCDD in mixture with humic substances In vitro assessment of AhR-mediated activities of TCDD in mixture with humic substances
skos:prefLabel
In vitro assessment of AhR-mediated activities of TCDD in mixture with humic substances In vitro assessment of AhR-mediated activities of TCDD in mixture with humic substances
skos:notation
RIV/00216224:14310/09:00029898!RIV10-MSM-14310___
n3:aktivita
n10:P n10:Z
n3:aktivity
P(GP525/08/P464), Z(MSM0021622412)
n3:cisloPeriodika
11
n3:dodaniDat
n14:2010
n3:domaciTvurceVysledku
n6:9372318 n6:2423685
n3:druhVysledku
n4:J
n3:duvernostUdaju
n18:S
n3:entitaPredkladatele
n8:predkladatel
n3:idSjednocenehoVysledku
318915
n3:idVysledku
RIV/00216224:14310/09:00029898
n3:jazykVysledku
n12:eng
n3:klicovaSlova
Natural organic matter; AhR; Mixture; Interaction
n3:klicoveSlovo
n9:AhR n9:Interaction n9:Mixture n9:Natural%20organic%20matter
n3:kodStatuVydavatele
GB - Spojené království Velké Británie a Severního Irska
n3:kontrolniKodProRIV
[454F010A953C]
n3:nazevZdroje
Chemosphere
n3:obor
n11:DJ
n3:pocetDomacichTvurcuVysledku
2
n3:pocetTvurcuVysledku
3
n3:projekt
n15:GP525%2F08%2FP464
n3:rokUplatneniVysledku
n14:2009
n3:svazekPeriodika
76
n3:tvurceVysledku
Bittner, Michal Hilscherová, Klára John, Giesy
n3:wos
000270124800009
n3:zamer
n17:MSM0021622412
s:issn
0045-6535
s:numberOfPages
4
n19:organizacniJednotka
14310