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Statements

Subject Item
n2:RIV%2F00216224%3A14310%2F09%3A00029428%21RIV10-MSM-14310___
rdf:type
n10:Vysledek skos:Concept
dcterms:description
Current computational tools to assist experimentalists for the design and engineering of proteins with desired catalytic properties are reviewed. The applications of these tools for de novo design of protein active sites, optimization of substrate access and product exit pathways, redesign of protein protein interfaces, identification of neutral/advantageous/deleterious mutations in the libraries from directed evolution and stabilization of protein structures are described. Remarkable progress is seen in de novo design of enzymes catalyzing a chemical reaction for which a natural biocatalyst does not exist. Yet, constructed biocatalysts do not match natural enzymes in their efficiency, suggesting that more research is needed to capture all the important features of natural biocatalysts in theoretical designs. Current computational tools to assist experimentalists for the design and engineering of proteins with desired catalytic properties are reviewed. The applications of these tools for de novo design of protein active sites, optimization of substrate access and product exit pathways, redesign of protein protein interfaces, identification of neutral/advantageous/deleterious mutations in the libraries from directed evolution and stabilization of protein structures are described. Remarkable progress is seen in de novo design of enzymes catalyzing a chemical reaction for which a natural biocatalyst does not exist. Yet, constructed biocatalysts do not match natural enzymes in their efficiency, suggesting that more research is needed to capture all the important features of natural biocatalysts in theoretical designs.
dcterms:title
Computational Tools for Designing and Engineering Biocatalysts. Computational Tools for Designing and Engineering Biocatalysts.
skos:prefLabel
Computational Tools for Designing and Engineering Biocatalysts. Computational Tools for Designing and Engineering Biocatalysts.
skos:notation
RIV/00216224:14310/09:00029428!RIV10-MSM-14310___
n3:aktivita
n17:Z n17:P
n3:aktivity
P(GA201/07/0927), P(GA203/08/0114), P(LC06010), Z(MSM0021622412), Z(MSM0021622413)
n3:cisloPeriodika
13
n3:dodaniDat
n14:2010
n3:domaciTvurceVysledku
n11:6084559 n11:1030175
n3:druhVysledku
n18:J
n3:duvernostUdaju
n16:S
n3:entitaPredkladatele
n12:predkladatel
n3:idSjednocenehoVysledku
307959
n3:idVysledku
RIV/00216224:14310/09:00029428
n3:jazykVysledku
n7:eng
n3:klicovaSlova
protein; engineering; biocatalysts
n3:klicoveSlovo
n6:biocatalysts n6:protein n6:engineering
n3:kodStatuVydavatele
GB - Spojené království Velké Británie a Severního Irska
n3:kontrolniKodProRIV
[11ACF1F4BBE8]
n3:nazevZdroje
CURRENT OPINION IN BIOLOGICAL CHEMISTRY
n3:obor
n9:CE
n3:pocetDomacichTvurcuVysledku
2
n3:pocetTvurcuVysledku
2
n3:projekt
n4:GA203%2F08%2F0114 n4:GA201%2F07%2F0927 n4:LC06010
n3:rokUplatneniVysledku
n14:2009
n3:svazekPeriodika
1
n3:tvurceVysledku
Damborský, Jiří Brezovský, Jan
n3:wos
000266192400005
n3:zamer
n19:MSM0021622412 n19:MSM0021622413
s:issn
1367-5931
s:numberOfPages
9
n15:organizacniJednotka
14310