This HTML5 document contains 53 embedded RDF statements represented using HTML+Microdata notation.

The embedded RDF content will be recognized by any processor of HTML5 Microdata.

Namespace Prefixes

PrefixIRI
dctermshttp://purl.org/dc/terms/
n14http://localhost/temp/predkladatel/
n6http://linked.opendata.cz/resource/domain/vavai/projekt/
n4http://linked.opendata.cz/resource/domain/vavai/riv/tvurce/
n19http://linked.opendata.cz/resource/domain/vavai/vysledek/RIV%2F00216224%3A14310%2F09%3A00028664%21RIV11-AV0-14310___/
n12http://linked.opendata.cz/ontology/domain/vavai/
n16http://linked.opendata.cz/resource/domain/vavai/zamer/
shttp://schema.org/
skoshttp://www.w3.org/2004/02/skos/core#
n3http://linked.opendata.cz/ontology/domain/vavai/riv/
n2http://linked.opendata.cz/resource/domain/vavai/vysledek/
rdfhttp://www.w3.org/1999/02/22-rdf-syntax-ns#
n9http://linked.opendata.cz/ontology/domain/vavai/riv/klicoveSlovo/
n8http://linked.opendata.cz/ontology/domain/vavai/riv/duvernostUdaju/
xsdhhttp://www.w3.org/2001/XMLSchema#
n18http://linked.opendata.cz/ontology/domain/vavai/riv/jazykVysledku/
n10http://linked.opendata.cz/ontology/domain/vavai/riv/aktivita/
n15http://linked.opendata.cz/ontology/domain/vavai/riv/druhVysledku/
n13http://linked.opendata.cz/ontology/domain/vavai/riv/obor/
n17http://reference.data.gov.uk/id/gregorian-year/

Statements

Subject Item
n2:RIV%2F00216224%3A14310%2F09%3A00028664%21RIV11-AV0-14310___
rdf:type
n12:Vysledek skos:Concept
dcterms:description
We analyzed the effect of epigenetic changes induced by a histone deacetylase inhibitor (HDACi) on the nuclear radial rearrangement of select genomic regions and chromosomes. Three-dimensional analysis of nuclear radial distributions revealed that this increase in H3K9 acetylation was often associated with a repositioning of select loci and chromosomes toward the nuclear center. On the other hand, many centromeres resided sites more toward the nuclear periphery, similar to sites occupied by chromosome X. In more than two-thirds of events analyzed, central nuclear positioning correlated with a high level of H3K9 acetylation, while more peripheral positioning within interphase nuclei correlated with a lower level of acetylation. This was observed for the gene-rich chromosomes 17 and 19, TP53, and CCND / genes as well as for gene-poor chromosome 18, APC gene, regions of low transcriptional activity (anti-RIDGEs), and the relatively transcriptionally less active chromosome X. We analyzed the effect of epigenetic changes induced by a histone deacetylase inhibitor (HDACi) on the nuclear radial rearrangement of select genomic regions and chromosomes. Three-dimensional analysis of nuclear radial distributions revealed that this increase in H3K9 acetylation was often associated with a repositioning of select loci and chromosomes toward the nuclear center. On the other hand, many centromeres resided sites more toward the nuclear periphery, similar to sites occupied by chromosome X. In more than two-thirds of events analyzed, central nuclear positioning correlated with a high level of H3K9 acetylation, while more peripheral positioning within interphase nuclei correlated with a lower level of acetylation. This was observed for the gene-rich chromosomes 17 and 19, TP53, and CCND / genes as well as for gene-poor chromosome 18, APC gene, regions of low transcriptional activity (anti-RIDGEs), and the relatively transcriptionally less active chromosome X.
dcterms:title
H3K9 Acetylation and Radial Chromatin Positioning H3K9 Acetylation and Radial Chromatin Positioning
skos:prefLabel
H3K9 Acetylation and Radial Chromatin Positioning H3K9 Acetylation and Radial Chromatin Positioning
skos:notation
RIV/00216224:14310/09:00028664!RIV11-AV0-14310___
n3:aktivita
n10:Z n10:P
n3:aktivity
P(1QS500040508), P(GA204/06/0978), P(IAA5004306), P(LC06027), P(LC535), Z(AV0Z50040507), Z(AV0Z50040702)
n3:cisloPeriodika
1
n3:dodaniDat
n17:2011
n3:domaciTvurceVysledku
n4:5374650 n4:8491313 n4:1587242 n4:1495151 n4:4873130
n3:druhVysledku
n15:J
n3:duvernostUdaju
n8:S
n3:entitaPredkladatele
n19:predkladatel
n3:idSjednocenehoVysledku
318254
n3:idVysledku
RIV/00216224:14310/09:00028664
n3:jazykVysledku
n18:eng
n3:klicovaSlova
HDACi; epigenetics
n3:klicoveSlovo
n9:HDACi n9:epigenetics
n3:kodStatuVydavatele
US - Spojené státy americké
n3:kontrolniKodProRIV
[FE21626138A6]
n3:nazevZdroje
Journal of cellular physiology
n3:obor
n13:EB
n3:pocetDomacichTvurcuVysledku
5
n3:pocetTvurcuVysledku
6
n3:projekt
n6:LC06027 n6:IAA5004306 n6:LC535 n6:1QS500040508 n6:GA204%2F06%2F0978
n3:rokUplatneniVysledku
n17:2009
n3:svazekPeriodika
220
n3:tvurceVysledku
Bártová, Eva Kozubek, Stanislav Harničarová, Andrea Strašák, Luděk Galiová, Gabriela Krejčí, Jana
n3:wos
000266672400011
n3:zamer
n16:AV0Z50040507 n16:AV0Z50040702
s:issn
0021-9541
s:numberOfPages
11
n14:organizacniJednotka
14310