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Statements

Subject Item
n2:RIV%2F00216224%3A14310%2F08%3A00042180%21RIV11-MSM-14310___
rdf:type
skos:Concept n18:Vysledek
dcterms:description
The polymorphism of major histocompatibility complex (MHC) genes was investigated in relation to parasitism in several populations of chub (Leuciscus cephalus) from different European rivers. The MHC genes are the most polymorphic loci known for vertebrates, whereas tree possible hypotheses of parasite-mediated selection driving an extensive MHC diversity (i.e. overdominance hypothesis, frequency dependent selection hypothesis and hypothesis of optimal number of MHC alleles) have been proposed. Hence, these genes are convenient model for elucidating the host-parasite relationships. It has been predicted that the populations with more genetic variability of MHC will have more diverse array of parasites. The antigens derived from parasites (possible important selective agents) interact with peptide binding region of MHC II molecules, on that account the present study was focused on genetic variability of the exon 2 (DAB1 and DAB3 genes), which encodes the beta 1 domain of the peptide binding region. The polymorphism of major histocompatibility complex (MHC) genes was investigated in relation to parasitism in several populations of chub (Leuciscus cephalus) from different European rivers. The MHC genes are the most polymorphic loci known for vertebrates, whereas tree possible hypotheses of parasite-mediated selection driving an extensive MHC diversity (i.e. overdominance hypothesis, frequency dependent selection hypothesis and hypothesis of optimal number of MHC alleles) have been proposed. Hence, these genes are convenient model for elucidating the host-parasite relationships. It has been predicted that the populations with more genetic variability of MHC will have more diverse array of parasites. The antigens derived from parasites (possible important selective agents) interact with peptide binding region of MHC II molecules, on that account the present study was focused on genetic variability of the exon 2 (DAB1 and DAB3 genes), which encodes the beta 1 domain of the peptide binding region.
dcterms:title
Polymorphism of DAB genes and variation in parasite species diversity in European populations of chub (Leuciscus cephalus) Polymorphism of DAB genes and variation in parasite species diversity in European populations of chub (Leuciscus cephalus)
skos:prefLabel
Polymorphism of DAB genes and variation in parasite species diversity in European populations of chub (Leuciscus cephalus) Polymorphism of DAB genes and variation in parasite species diversity in European populations of chub (Leuciscus cephalus)
skos:notation
RIV/00216224:14310/08:00042180!RIV11-MSM-14310___
n4:aktivita
n17:P n17:Z
n4:aktivity
P(LC522), Z(MSM0021622416)
n4:dodaniDat
n5:2011
n4:domaciTvurceVysledku
n6:7166680 n6:7279329 n6:3741613
n4:druhVysledku
n13:O
n4:duvernostUdaju
n7:S
n4:entitaPredkladatele
n8:predkladatel
n4:idSjednocenehoVysledku
387437
n4:idVysledku
RIV/00216224:14310/08:00042180
n4:jazykVysledku
n11:eng
n4:klicovaSlova
MHC; parasite; fish
n4:klicoveSlovo
n9:MHC n9:fish n9:parasite
n4:kontrolniKodProRIV
[C12C336EB75D]
n4:obor
n10:EG
n4:pocetDomacichTvurcuVysledku
3
n4:pocetTvurcuVysledku
3
n4:projekt
n12:LC522
n4:rokUplatneniVysledku
n5:2008
n4:tvurceVysledku
Vetešníková Šimková, Andrea Seifertová, Mária Vyskočilová, Martina
n4:zamer
n15:MSM0021622416
n16:organizacniJednotka
14310