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Statements

Subject Item
n2:RIV%2F00216224%3A14310%2F08%3A00027622%21RIV10-MSM-14310___
rdf:type
skos:Concept n19:Vysledek
dcterms:description
Many aspects of plant development, including patterning and tropisms, are largely dependent on the asymmetric distribution of the plant signaling molecule auxin. Auxin transport inhibitors (ATIs), which interfere with directional auxin transport, have been essential tools in formulating this concept. However, despite the use of ATIs in plant research for many decades, the mechanism of ATI action has remained largely elusive. Using real-time live-cell microscopy, we show here that prominent ATIs such as 2,3,5-triiodobenzoic acid (TIBA) and 2-(1-pyrenoyl) benzoic acid (PBA) inhibit vesicle trafficking in plant, yeast, and mammalian cells. Effects on micropinocytosis, rab5-labeled endosomal motility at the periphery of HeLa cells and on fibroblast mobility indicate that ATIs influence actin cytoskeleton. Visualization of actin cytoskeleton dynamics in plants, yeast, and mammalian cells show that ATIs stabilize actin. Many aspects of plant development, including patterning and tropisms, are largely dependent on the asymmetric distribution of the plant signaling molecule auxin. Auxin transport inhibitors (ATIs), which interfere with directional auxin transport, have been essential tools in formulating this concept. However, despite the use of ATIs in plant research for many decades, the mechanism of ATI action has remained largely elusive. Using real-time live-cell microscopy, we show here that prominent ATIs such as 2,3,5-triiodobenzoic acid (TIBA) and 2-(1-pyrenoyl) benzoic acid (PBA) inhibit vesicle trafficking in plant, yeast, and mammalian cells. Effects on micropinocytosis, rab5-labeled endosomal motility at the periphery of HeLa cells and on fibroblast mobility indicate that ATIs influence actin cytoskeleton. Visualization of actin cytoskeleton dynamics in plants, yeast, and mammalian cells show that ATIs stabilize actin.
dcterms:title
Auxin transport inhibitors impair vesicle motility and actin cytoskeleton dynamics in diverse eukaryotes Auxin transport inhibitors impair vesicle motility and actin cytoskeleton dynamics in diverse eukaryotes
skos:prefLabel
Auxin transport inhibitors impair vesicle motility and actin cytoskeleton dynamics in diverse eukaryotes Auxin transport inhibitors impair vesicle motility and actin cytoskeleton dynamics in diverse eukaryotes
skos:notation
RIV/00216224:14310/08:00027622!RIV10-MSM-14310___
n4:aktivita
n10:P n10:Z
n4:aktivity
P(GA204/05/0838), P(IAA601630703), P(KJB600380604), P(LC06034), Z(AV0Z50200510), Z(AV0Z50380511), Z(MSM0021622415)
n4:cisloPeriodika
11
n4:dodaniDat
n13:2010
n4:domaciTvurceVysledku
n16:3730832
n4:druhVysledku
n8:J
n4:duvernostUdaju
n5:S
n4:entitaPredkladatele
n7:predkladatel
n4:idSjednocenehoVysledku
357494
n4:idVysledku
RIV/00216224:14310/08:00027622
n4:jazykVysledku
n12:eng
n4:klicovaSlova
PIN proteins; plant development; vesicle traffic; auxin efflux inhibitors
n4:klicoveSlovo
n6:plant%20development n6:vesicle%20traffic n6:PIN%20proteins n6:auxin%20efflux%20inhibitors
n4:kodStatuVydavatele
US - Spojené státy americké
n4:kontrolniKodProRIV
[454E3796B7A3]
n4:nazevZdroje
Proceedings of the National Academy of Sciences of the United States of America
n4:obor
n15:EB
n4:pocetDomacichTvurcuVysledku
1
n4:pocetTvurcuVysledku
20
n4:projekt
n14:KJB600380604 n14:GA204%2F05%2F0838 n14:IAA601630703 n14:LC06034
n4:rokUplatneniVysledku
n13:2008
n4:svazekPeriodika
105
n4:tvurceVysledku
Brock, Roland Tominaga, Motoki Spang, Anne Zažímalová, Eva Robinson, David G Stierhof, York-Dieter Tejos, Ricardo Gadella, Jr, Theodorus W. J. Paciorek, Tomasz Dhonukshe, Pankaj Hašek, Jiří Grigoriev, Ilya Oiwa, Kazuhiro Akhmanova, Anna Petrášek, Jan Seifertová, Daniela Meiselm, Lee A. Ueda, Takashi Fischer, Rainer Friml, Jiří
n4:wos
000254263300074
n4:zamer
n17:MSM0021622415 n17:AV0Z50380511 n17:AV0Z50200510
s:issn
0027-8424
s:numberOfPages
6
n18:organizacniJednotka
14310