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Statements

Subject Item
n2:RIV%2F00216224%3A14310%2F08%3A00026760%21RIV10-MSM-14310___
rdf:type
skos:Concept n10:Vysledek
rdfs:seeAlso
www.gmi.oeaw.ac.at
dcterms:description
Homologous recombination (HR) is a process widespread in nature and essential to maintain the integrity of the genome via repair of DNA double-strand breaks (DSBs). Several models were proposed to understand the mechanism of double-strand break repair by HR, identify separate steps and role of the individual proteins involved. The Mus81/MMS4 complex is a DNA structure-specific endonuclease involved in replication fork stability and DNA repair. It seems from genetic experiments that Mus81/MMS4 could interact with Srs2, a helicase which on one hand prevents untimely recombination and on the other hand is necessary for certain pathways of homologous recombination. In our study, we confirmed the interaction between Mus81/MMS4 and Srs2. We then analyzed the stimulation of Mus81/MMS4 nuclease activity by Srs2 and we found out that this stimulation depends on the DNA subtrate involved in the reaction. Our experiments also indicate that the interaction between Mus81/MMS4 and Srs2 is specific. Homologous recombination (HR) is a process widespread in nature and essential to maintain the integrity of the genome via repair of DNA double-strand breaks (DSBs). Several models were proposed to understand the mechanism of double-strand break repair by HR, identify separate steps and role of the individual proteins involved. The Mus81/MMS4 complex is a DNA structure-specific endonuclease involved in replication fork stability and DNA repair. It seems from genetic experiments that Mus81/MMS4 could interact with Srs2, a helicase which on one hand prevents untimely recombination and on the other hand is necessary for certain pathways of homologous recombination. In our study, we confirmed the interaction between Mus81/MMS4 and Srs2. We then analyzed the stimulation of Mus81/MMS4 nuclease activity by Srs2 and we found out that this stimulation depends on the DNA subtrate involved in the reaction. Our experiments also indicate that the interaction between Mus81/MMS4 and Srs2 is specific.
dcterms:title
Role of SRS2 and Mus81/MMS4 in processing recombination/replication intermediates . Role of SRS2 and Mus81/MMS4 in processing recombination/replication intermediates .
skos:prefLabel
Role of SRS2 and Mus81/MMS4 in processing recombination/replication intermediates . Role of SRS2 and Mus81/MMS4 in processing recombination/replication intermediates .
skos:notation
RIV/00216224:14310/08:00026760!RIV10-MSM-14310___
n3:aktivita
n6:Z
n3:aktivity
Z(MSM 143100005), Z(MSM0021622413)
n3:dodaniDat
n16:2010
n3:domaciTvurceVysledku
n17:3357864
n3:druhVysledku
n15:A
n3:duvernostUdaju
n14:S
n3:entitaPredkladatele
n12:predkladatel
n3:idSjednocenehoVysledku
384478
n3:idVysledku
RIV/00216224:14310/08:00026760
n3:jazykVysledku
n13:eng
n3:klicovaSlova
DNA repair; homologous recombination; nuclease activity; MUS81; SRS2
n3:klicoveSlovo
n4:MUS81 n4:nuclease%20activity n4:SRS2 n4:homologous%20recombination n4:DNA%20repair
n3:kodPristupu
n9:V
n3:kontrolniKodProRIV
[D6F954AE5732]
n3:obor
n7:CE
n3:pocetDomacichTvurcuVysledku
1
n3:pocetTvurcuVysledku
1
n3:rokUplatneniVysledku
n16:2008
n3:tvurceVysledku
Matulová, Petra
n3:zamer
n8:MSM0021622413 n8:MSM%20143100005
n19:organizacniJednotka
14310