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Statements

Subject Item
n2:RIV%2F00216224%3A14310%2F08%3A00026663%21RIV11-MSM-14310___
rdf:type
skos:Concept n19:Vysledek
dcterms:description
The structure–function relationships for haloalkane dehalogenases, representing one of the best characterized families of enzymes involved in degradation of halogenated compounds is described. A substantial amount of mechanistic and structural information is currently available on haloalkane dehalogenases, providing good theoretical framework for their modification by protein engineering. Examples of constructed mutants include variants with modified: (1) activity, (2) thermostability, (3) substrate specificity and (4) enantioselectivity. Some variants carried mutations in the tunnels, connecting the buried active site with surrounding solvent, rather in the active site itself. Mutagenesis in the residues lining the protein tunnels represents a new paradigm in protein engineering. The structure–function relationships for haloalkane dehalogenases, representing one of the best characterized families of enzymes involved in degradation of halogenated compounds is described. A substantial amount of mechanistic and structural information is currently available on haloalkane dehalogenases, providing good theoretical framework for their modification by protein engineering. Examples of constructed mutants include variants with modified: (1) activity, (2) thermostability, (3) substrate specificity and (4) enantioselectivity. Some variants carried mutations in the tunnels, connecting the buried active site with surrounding solvent, rather in the active site itself. Mutagenesis in the residues lining the protein tunnels represents a new paradigm in protein engineering.
dcterms:title
Structure-Function Relationships and Engineering of Haloalkane Dehalogenases Structure-Function Relationships and Engineering of Haloalkane Dehalogenases
skos:prefLabel
Structure-Function Relationships and Engineering of Haloalkane Dehalogenases Structure-Function Relationships and Engineering of Haloalkane Dehalogenases
skos:notation
RIV/00216224:14310/08:00026663!RIV11-MSM-14310___
n3:aktivita
n4:P n4:Z
n3:aktivity
P(LC06010), Z(MSM0021622412)
n3:dodaniDat
n8:2011
n3:domaciTvurceVysledku
n6:6084559 n6:9072500 n6:4187911 n6:1030175 n6:7612656
n3:druhVysledku
n9:C
n3:duvernostUdaju
n18:S
n3:entitaPredkladatele
n17:predkladatel
n3:idSjednocenehoVysledku
397860
n3:idVysledku
RIV/00216224:14310/08:00026663
n3:jazykVysledku
n11:eng
n3:klicovaSlova
QSAR; haloalkan dehalogenases
n3:klicoveSlovo
n14:haloalkan%20dehalogenases n14:QSAR
n3:kontrolniKodProRIV
[F3D0C69C61B0]
n3:mistoVydani
Heidelberg
n3:nazevEdiceCisloSvazku
Handbooks, 1
n3:nazevZdroje
Handbook of Hydrocarbon and Lipid Microbiology
n3:obor
n16:CE
n3:pocetDomacichTvurcuVysledku
5
n3:pocetStranKnihy
4480
n3:pocetTvurcuVysledku
5
n3:projekt
n12:LC06010
n3:rokUplatneniVysledku
n8:2008
n3:tvurceVysledku
Brezovský, Jan Chovancová, Eva Pavlová, Martina Chaloupková, Radka Damborský, Jiří
n3:zamer
n21:MSM0021622412
s:numberOfPages
18
n20:hasPublisher
Springer-Verlag
n5:isbn
978-3-540-77584-3
n15:organizacniJednotka
14310