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Statements

Subject Item
n2:RIV%2F00216224%3A14310%2F08%3A00026609%21RIV10-MSM-14310___
rdf:type
skos:Concept n7:Vysledek
dcterms:description
The opportunistic pathogen Pseudomonas aeruginosa contains several carbohydrate-binding proteins, among which is the P. aeruginosa lectin I (PA-IL), which displays affinity for a-galactosylated glycans. Glycan arrays were screened and demonstrated stronger binding of PA-IL toward aGal1-4bGal-terminating structures and weaker binding to aGal1-3bGal ones in order to determine which human glycoconjugates could play a role in the carbohydrate-mediated adhesion of the bacteria. This was confirmed in vivo by testing the binding of the lectin to Burkitt lymphoma cells that present large amounts of globotriaosylceramide antigen Gb3/CD77/Pk. Trisaccharide moieties of Gb3 and isoglobotriaosylceramide were tested by titration microcalorimetry, and both displayed similar affinity to PA-IL in solution. The opportunistic pathogen Pseudomonas aeruginosa contains several carbohydrate-binding proteins, among which is the P. aeruginosa lectin I (PA-IL), which displays affinity for a-galactosylated glycans. Glycan arrays were screened and demonstrated stronger binding of PA-IL toward aGal1-4bGal-terminating structures and weaker binding to aGal1-3bGal ones in order to determine which human glycoconjugates could play a role in the carbohydrate-mediated adhesion of the bacteria. This was confirmed in vivo by testing the binding of the lectin to Burkitt lymphoma cells that present large amounts of globotriaosylceramide antigen Gb3/CD77/Pk. Trisaccharide moieties of Gb3 and isoglobotriaosylceramide were tested by titration microcalorimetry, and both displayed similar affinity to PA-IL in solution.
dcterms:title
Structural Basis of the Preferential Binding for Globo-Series Glycosphingolipids Displayed by Pseudomonas aeruginosa Lectin I Structural Basis of the Preferential Binding for Globo-Series Glycosphingolipids Displayed by Pseudomonas aeruginosa Lectin I
skos:prefLabel
Structural Basis of the Preferential Binding for Globo-Series Glycosphingolipids Displayed by Pseudomonas aeruginosa Lectin I Structural Basis of the Preferential Binding for Globo-Series Glycosphingolipids Displayed by Pseudomonas aeruginosa Lectin I
skos:notation
RIV/00216224:14310/08:00026609!RIV10-MSM-14310___
n3:aktivita
n12:Z
n3:aktivity
Z(MSM0021622413)
n3:cisloPeriodika
4
n3:dodaniDat
n14:2010
n3:domaciTvurceVysledku
n13:5522064 n13:5616697
n3:druhVysledku
n18:J
n3:duvernostUdaju
n11:S
n3:entitaPredkladatele
n6:predkladatel
n3:idSjednocenehoVysledku
397762
n3:idVysledku
RIV/00216224:14310/08:00026609
n3:jazykVysledku
n17:eng
n3:klicovaSlova
pseudomonas aeruginosa; lectin; molecular modeling; structure; glycosphinglipid; oligosaccharides
n3:klicoveSlovo
n4:oligosaccharides n4:molecular%20modeling n4:lectin n4:pseudomonas%20aeruginosa n4:structure n4:glycosphinglipid
n3:kodStatuVydavatele
NL - Nizozemsko
n3:kontrolniKodProRIV
[4DD8367C569D]
n3:nazevZdroje
Journal of Molecular Biology
n3:obor
n16:BO
n3:pocetDomacichTvurcuVysledku
2
n3:pocetTvurcuVysledku
9
n3:rokUplatneniVysledku
n14:2008
n3:svazekPeriodika
383
n3:tvurceVysledku
Blanchard, Bertrand Hollwille, Emilie Nurisso, Alessandra Wimmerová, Michaela Tetaud, Cecile Imberty, Anne Varrotte, Annabelle Pokorná, Martina Wiells, Joele
n3:wos
000260533800009
n3:zamer
n8:MSM0021622413
s:issn
0022-2836
s:numberOfPages
17
n15:organizacniJednotka
14310