This HTML5 document contains 57 embedded RDF statements represented using HTML+Microdata notation.

The embedded RDF content will be recognized by any processor of HTML5 Microdata.

Namespace Prefixes

PrefixIRI
n16http://linked.opendata.cz/resource/domain/vavai/vysledek/RIV%2F00216224%3A14310%2F08%3A00026088%21RIV10-MSM-14310___/
dctermshttp://purl.org/dc/terms/
n12http://localhost/temp/predkladatel/
n8http://linked.opendata.cz/resource/domain/vavai/projekt/
n6http://linked.opendata.cz/resource/domain/vavai/riv/tvurce/
n15http://linked.opendata.cz/ontology/domain/vavai/
n19http://linked.opendata.cz/resource/domain/vavai/zamer/
shttp://schema.org/
skoshttp://www.w3.org/2004/02/skos/core#
n3http://linked.opendata.cz/ontology/domain/vavai/riv/
n2http://linked.opendata.cz/resource/domain/vavai/vysledek/
rdfhttp://www.w3.org/1999/02/22-rdf-syntax-ns#
n5http://linked.opendata.cz/ontology/domain/vavai/riv/klicoveSlovo/
n10http://linked.opendata.cz/ontology/domain/vavai/riv/duvernostUdaju/
xsdhhttp://www.w3.org/2001/XMLSchema#
n18http://linked.opendata.cz/ontology/domain/vavai/riv/jazykVysledku/
n4http://linked.opendata.cz/ontology/domain/vavai/riv/aktivita/
n17http://linked.opendata.cz/ontology/domain/vavai/riv/druhVysledku/
n11http://linked.opendata.cz/ontology/domain/vavai/riv/obor/
n9http://reference.data.gov.uk/id/gregorian-year/

Statements

Subject Item
n2:RIV%2F00216224%3A14310%2F08%3A00026088%21RIV10-MSM-14310___
rdf:type
skos:Concept n15:Vysledek
dcterms:description
The novel methylphosphonic acid monoethylester (H4dotpOEt) has been synthesized and characterized and their complexes with Sm(III) and Ho(III) ions were studied. Dissociation constants of the ligand are lower than those of H4dota. The stability constants of the Ln(III)-H4dotpOEt complexes are surprisingly much lower that those of H4dota probably due to a lower coordination ability of the phosphonate monoester groups. Acid-assisted decomplexation studies have shown that both complexes are less kinetically inert than the H4dota complexes, but still much more inert than complexes of open-chain ligands. Nevertheless, the synthesis of 153Sm and 166Ho complexes with this ligand led to stable complexes both in vitro and in vivo. A very low binding of these complexes to hydroxyapatite (HA) and calcified tissues was observed confirming the assumption that a fully ionized phosphonate group(s) is necessary for a strong bone affinity. Both complexes show similar behaviour in vivo. The novel methylphosphonic acid monoethylester (H4dotpOEt) has been synthesized and characterized and their complexes with Sm(III) and Ho(III) ions were studied. Dissociation constants of the ligand are lower than those of H4dota. The stability constants of the Ln(III)-H4dotpOEt complexes are surprisingly much lower that those of H4dota probably due to a lower coordination ability of the phosphonate monoester groups. Acid-assisted decomplexation studies have shown that both complexes are less kinetically inert than the H4dota complexes, but still much more inert than complexes of open-chain ligands. Nevertheless, the synthesis of 153Sm and 166Ho complexes with this ligand led to stable complexes both in vitro and in vivo. A very low binding of these complexes to hydroxyapatite (HA) and calcified tissues was observed confirming the assumption that a fully ionized phosphonate group(s) is necessary for a strong bone affinity. Both complexes show similar behaviour in vivo.
dcterms:title
Chemical and biological evaluation of 153Sm and 166Ho complexes of 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetrakis(methylphosphonic acid monoethylester) (H4dotpOEt) Chemical and biological evaluation of 153Sm and 166Ho complexes of 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetrakis(methylphosphonic acid monoethylester) (H4dotpOEt)
skos:prefLabel
Chemical and biological evaluation of 153Sm and 166Ho complexes of 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetrakis(methylphosphonic acid monoethylester) (H4dotpOEt) Chemical and biological evaluation of 153Sm and 166Ho complexes of 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetrakis(methylphosphonic acid monoethylester) (H4dotpOEt)
skos:notation
RIV/00216224:14310/08:00026088!RIV10-MSM-14310___
n3:aktivita
n4:P n4:Z n4:S
n3:aktivity
P(LC06035), P(OC 179), S, Z(MSM0021620857)
n3:cisloPeriodika
7
n3:dodaniDat
n9:2010
n3:domaciTvurceVysledku
n6:3978877 n6:5135001 n6:9007563
n3:druhVysledku
n17:J
n3:duvernostUdaju
n10:S
n3:entitaPredkladatele
n16:predkladatel
n3:idSjednocenehoVysledku
359700
n3:idVysledku
RIV/00216224:14310/08:00026088
n3:jazykVysledku
n18:eng
n3:klicovaSlova
Radiopharmaceuticals; macrocyclic and phosphonate complexes; cyclen derivative; DOTA analogue; lanthanide complexes; radiolanthanides; biodistribution; stability constants; formation and decomplexation kinetics
n3:klicoveSlovo
n5:DOTA%20analogue n5:macrocyclic%20and%20phosphonate%20complexes n5:cyclen%20derivative n5:biodistribution n5:formation%20and%20decomplexation%20kinetics n5:stability%20constants n5:lanthanide%20complexes n5:Radiopharmaceuticals n5:radiolanthanides
n3:kodStatuVydavatele
NL - Nizozemsko
n3:kontrolniKodProRIV
[33A1DB583D5B]
n3:nazevZdroje
Journal of Inorganic Biochemistry
n3:obor
n11:CA
n3:pocetDomacichTvurcuVysledku
3
n3:pocetTvurcuVysledku
8
n3:projekt
n8:LC06035 n8:OC%20179
n3:rokUplatneniVysledku
n9:2008
n3:svazekPeriodika
102
n3:tvurceVysledku
Hermann, Petr Lubal, Přemysl Marques, Fernanda Vaněk, Jakub Jandurová, Zuzana Santos, Isabel Foerstrová, Michaela Lurdes, Gano
n3:wos
000256924600014
n3:zamer
n19:MSM0021620857
s:issn
0162-0134
s:numberOfPages
10
n12:organizacniJednotka
14310