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Statements

Subject Item
n2:RIV%2F00216224%3A14310%2F08%3A00024950%21RIV11-GA0-14310___
rdf:type
n8:Vysledek skos:Concept
dcterms:description
Bones are preferential targets of disseminating prostate cancer cells. Homing and activity of cancer cells in the bone microenvironment as well as specific mechanisms used by tumor cells remain to be elucidated. Te aim of this study is to describe the effects of three members of the TGFb protein family (TGFb, BMP-7 and GDF-15) on RANKL-induced osteoclast differentiation of murine cells RAW264.7. These proteins are secreted by prostate cancer cells LNCaP, possess strong morphogenic effects and affect the bone microenvironment. We found that TGFb accelerated the RANKL-induced differentiation of RAW264.7 cells to active osteoclasts and induced expression of several osteoclast-associated genes. In contrast, the BMP-7 and GDF-15 cytokines suppressed the RANKL-induced osteoclast differentiation and silenced expression of the osteoclast-associated genes. We conclude that different members of the TGFb protein family play different roles in regulation of signals driving formation of osteoclasts. Bones are preferential targets of disseminating prostate cancer cells. Homing and activity of cancer cells in the bone microenvironment as well as specific mechanisms used by tumor cells remain to be elucidated. Te aim of this study is to describe the effects of three members of the TGFb protein family (TGFb, BMP-7 and GDF-15) on RANKL-induced osteoclast differentiation of murine cells RAW264.7. These proteins are secreted by prostate cancer cells LNCaP, possess strong morphogenic effects and affect the bone microenvironment. We found that TGFb accelerated the RANKL-induced differentiation of RAW264.7 cells to active osteoclasts and induced expression of several osteoclast-associated genes. In contrast, the BMP-7 and GDF-15 cytokines suppressed the RANKL-induced osteoclast differentiation and silenced expression of the osteoclast-associated genes. We conclude that different members of the TGFb protein family play different roles in regulation of signals driving formation of osteoclasts.
dcterms:title
The effects of TGFb proteins on osteoclast differentiation The effects of TGFb proteins on osteoclast differentiation
skos:prefLabel
The effects of TGFb proteins on osteoclast differentiation The effects of TGFb proteins on osteoclast differentiation
skos:notation
RIV/00216224:14310/08:00024950!RIV11-GA0-14310___
n3:aktivita
n21:Z n21:P
n3:aktivity
P(GA301/06/0036), P(GD204/08/H054), Z(MSM0021622415)
n3:dodaniDat
n11:2011
n3:domaciTvurceVysledku
n9:3101630 n9:6723381 n9:6659446 n9:6453376
n3:druhVysledku
n7:D
n3:duvernostUdaju
n16:S
n3:entitaPredkladatele
n6:predkladatel
n3:idSjednocenehoVysledku
365436
n3:idVysledku
RIV/00216224:14310/08:00024950
n3:jazykVysledku
n4:eng
n3:klicovaSlova
osteoclasts; TGF beta; prostate cancer
n3:klicoveSlovo
n14:TGF%20beta n14:prostate%20cancer n14:osteoclasts
n3:kontrolniKodProRIV
[2B7AF312C897]
n3:mistoKonaniAkce
Hersonissos, Greece
n3:mistoVydani
Hersonissos, Greece
n3:nazevZdroje
Proceedings of the abstracts of the 13th World Congress on Advances in Oncology and 11th International Symposium on Molecular Medicine
n3:obor
n20:EB
n3:pocetDomacichTvurcuVysledku
4
n3:pocetTvurcuVysledku
4
n3:projekt
n18:GA301%2F06%2F0036 n18:GD204%2F08%2FH054
n3:rokUplatneniVysledku
n11:2008
n3:tvurceVysledku
Souček, Karel Vaňhara, Petr Šmarda, Jan Slabáková, Eva
n3:typAkce
n13:WRD
n3:zahajeniAkce
2008-01-01+01:00
n3:zamer
n17:MSM0021622415
s:issn
1107-3756
s:numberOfPages
2
n5:hasPublisher
International Journal of Molecular Medicine Vol. 22, supplement 1, 2008
n19:organizacniJednotka
14310