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Statements

Subject Item
n2:RIV%2F00216224%3A14310%2F07%3A00041713%21RIV11-MSM-14310___
rdf:type
skos:Concept n13:Vysledek
dcterms:description
The genes of the major histocompatibility complex (MHC) are the most polymorphic loci known for vertebrates. The host- pathogen coevolution and parasite-driven balancing selection have a extensive contribution to the high level of allelic diversity in MHC genes. The polymorphism of MHC molecules can be extremely huge; there are a large number of genetic variants (alleles) at each genetic locus. Individuals with higher number of different MHC molecules are able to recognize a broader spectrum of pathogen or parasite derived antigens, and then pathogens or parasites evolve to evade common MHC genotypes, giving rare MHC genotypes a selective advantage. A common European cyprinid, the chub, Leuciscus cephalus (L.), was chosen as a model organism for investigating the hypothesis of pathogen-driven selection under natural conditions, mediated either through heterozygous advantage (overdominant selection) or negative frequency-dependent selection (rare allele advantage hypothesis). The genes of the major histocompatibility complex (MHC) are the most polymorphic loci known for vertebrates. The host- pathogen coevolution and parasite-driven balancing selection have a extensive contribution to the high level of allelic diversity in MHC genes. The polymorphism of MHC molecules can be extremely huge; there are a large number of genetic variants (alleles) at each genetic locus. Individuals with higher number of different MHC molecules are able to recognize a broader spectrum of pathogen or parasite derived antigens, and then pathogens or parasites evolve to evade common MHC genotypes, giving rare MHC genotypes a selective advantage. A common European cyprinid, the chub, Leuciscus cephalus (L.), was chosen as a model organism for investigating the hypothesis of pathogen-driven selection under natural conditions, mediated either through heterozygous advantage (overdominant selection) or negative frequency-dependent selection (rare allele advantage hypothesis).
dcterms:title
Genetic variability of MHC class IIB genes associated with parasite diversity in European populations of chub (Leuciscus cephalus Linnaeus, 1758) Genetic variability of MHC class IIB genes associated with parasite diversity in European populations of chub (Leuciscus cephalus Linnaeus, 1758)
skos:prefLabel
Genetic variability of MHC class IIB genes associated with parasite diversity in European populations of chub (Leuciscus cephalus Linnaeus, 1758) Genetic variability of MHC class IIB genes associated with parasite diversity in European populations of chub (Leuciscus cephalus Linnaeus, 1758)
skos:notation
RIV/00216224:14310/07:00041713!RIV11-MSM-14310___
n3:aktivita
n14:Z
n3:aktivity
Z(MSM0021622416)
n3:dodaniDat
n9:2011
n3:domaciTvurceVysledku
n8:9478426 n8:7166680 n8:7279329 n8:3741613
n3:druhVysledku
n5:O
n3:duvernostUdaju
n15:S
n3:entitaPredkladatele
n10:predkladatel
n3:idSjednocenehoVysledku
423143
n3:idVysledku
RIV/00216224:14310/07:00041713
n3:jazykVysledku
n12:eng
n3:klicovaSlova
MHC class IIB genes Cyprinidae Selection Polymorphism
n3:klicoveSlovo
n16:MHC%20class%20IIB%20genes%20Cyprinidae%20Selection%20Polymorphism
n3:kontrolniKodProRIV
[CE95E40EACF3]
n3:obor
n7:EH
n3:pocetDomacichTvurcuVysledku
4
n3:pocetTvurcuVysledku
4
n3:rokUplatneniVysledku
n9:2007
n3:tvurceVysledku
Seifertová, Mária Vetešníková Šimková, Andrea Vyskočilová, Martina Jarkovský, Jiří
n3:zamer
n4:MSM0021622416
n17:organizacniJednotka
14310