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Statements

Subject Item
n2:RIV%2F00216224%3A14310%2F07%3A00032343%21RIV10-MSM-14310___
rdf:type
n5:Vysledek skos:Concept
dcterms:description
Fits in a pocket: The binding mode of epothilone A (EpoA) to tubulin is determined by NMR spectroscopy in aqueous solution. The results explain the existing structure-activity relationship data for epothilones with both native and mutant tubulins, and support the existence of a common pharmacophore for EpoA and paclitaxel. Fits in a pocket: The binding mode of epothilone A (EpoA) to tubulin is determined by NMR spectroscopy in aqueous solution. The results explain the existing structure-activity relationship data for epothilones with both native and mutant tubulins, and support the existence of a common pharmacophore for EpoA and paclitaxel.
dcterms:title
Structural basis of the activity of the microtubule-stabilizing agent epothilone a studied by NMR spectroscopy in solution Structural basis of the activity of the microtubule-stabilizing agent epothilone a studied by NMR spectroscopy in solution
skos:prefLabel
Structural basis of the activity of the microtubule-stabilizing agent epothilone a studied by NMR spectroscopy in solution Structural basis of the activity of the microtubule-stabilizing agent epothilone a studied by NMR spectroscopy in solution
skos:notation
RIV/00216224:14310/07:00032343!RIV10-MSM-14310___
n4:aktivita
n14:V
n4:aktivity
V
n4:cisloPeriodika
11
n4:dodaniDat
n8:2010
n4:domaciTvurceVysledku
n17:7878788
n4:druhVysledku
n12:J
n4:duvernostUdaju
n15:S
n4:entitaPredkladatele
n13:predkladatel
n4:idSjednocenehoVysledku
452847
n4:idVysledku
RIV/00216224:14310/07:00032343
n4:jazykVysledku
n9:eng
n4:klicovaSlova
epothilones; NMR spectroscopy; structure elucidation; structure-activity relationships; tubulins
n4:klicoveSlovo
n10:tubulins n10:epothilones n10:structure-activity%20relationships n10:structure%20elucidation n10:NMR%20spectroscopy
n4:kodStatuVydavatele
DE - Spolková republika Německo
n4:kontrolniKodProRIV
[8F663B3C7587]
n4:nazevZdroje
Angewandte Chemie International Edition
n4:obor
n11:BO
n4:pocetDomacichTvurcuVysledku
1
n4:pocetTvurcuVysledku
7
n4:rokUplatneniVysledku
n8:2007
n4:svazekPeriodika
46
n4:tvurceVysledku
Kubíček, Karel Carlomagno, Teresa Reese, Marcel Sanchez-Pedregal, Victor M Griesinger, Christian Meiler, Jens Blommers, Marcel J
s:issn
1433-7851
s:numberOfPages
5
n3:organizacniJednotka
14310