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Statements

Subject Item
n2:RIV%2F00216224%3A14310%2F07%3A00022189%21RIV10-MSM-14310___
rdf:type
n6:Vysledek skos:Concept
dcterms:description
Explicit solvent Molecular Dynamics (MD) was used to describe the intrinsic flexibility of the Helix 42-44 portion of the 23S rRNA (abbreviated as Kt-42+rGAC; Kink-turn 42 and GTPase associated center rRNA). The bottom part of this molecule consists of alternating rigid and flexible segments. The first flexible segment (Hinge1) is the highly anharmonic Kink of Kt-42. The second one (Hinge2) is localized at the junction between Helix 42 and Helices 43/44. The rigid segments are the two arms of Helix 42 flanking the Kink. The whole molecule ends up with compact Helices 43/44 (Head) which appear to be modestly compressed towards the subunit in the H.m. x-ray structure. Overall, the Helix 42-44 rRNA is constructed as a sophisticated intrinsically flexible anisotropic molecular limb. The leading flexibility modes include bending at the hinges and twisting. Explicit solvent Molecular Dynamics (MD) was used to describe the intrinsic flexibility of the Helix 42-44 portion of the 23S rRNA (abbreviated as Kt-42+rGAC; Kink-turn 42 and GTPase associated center rRNA). The bottom part of this molecule consists of alternating rigid and flexible segments. The first flexible segment (Hinge1) is the highly anharmonic Kink of Kt-42. The second one (Hinge2) is localized at the junction between Helix 42 and Helices 43/44. The rigid segments are the two arms of Helix 42 flanking the Kink. The whole molecule ends up with compact Helices 43/44 (Head) which appear to be modestly compressed towards the subunit in the H.m. x-ray structure. Overall, the Helix 42-44 rRNA is constructed as a sophisticated intrinsically flexible anisotropic molecular limb. The leading flexibility modes include bending at the hinges and twisting.
dcterms:title
Elastic properties of ribosomal RNA building blocks: molecular dynamics of the GTPase-associated center rRNA Elastic properties of ribosomal RNA building blocks: molecular dynamics of the GTPase-associated center rRNA
skos:prefLabel
Elastic properties of ribosomal RNA building blocks: molecular dynamics of the GTPase-associated center rRNA Elastic properties of ribosomal RNA building blocks: molecular dynamics of the GTPase-associated center rRNA
skos:notation
RIV/00216224:14310/07:00022189!RIV10-MSM-14310___
n3:aktivita
n15:P n15:Z
n3:aktivity
P(1QS500040581), P(GA203/05/0009), P(GA203/05/0388), P(LC06030), Z(AV0Z50040507), Z(AV0Z50040702), Z(MSM0021622413)
n3:cisloPeriodika
12
n3:dodaniDat
n5:2010
n3:domaciTvurceVysledku
n7:4347374 n7:4585623 n7:3223779
n3:druhVysledku
n11:J
n3:duvernostUdaju
n19:S
n3:entitaPredkladatele
n9:predkladatel
n3:idSjednocenehoVysledku
419611
n3:idVysledku
RIV/00216224:14310/07:00022189
n3:jazykVysledku
n12:eng
n3:klicovaSlova
Molecular Dynamics; RNA Kink Turn; Ribosome; RNA flexibility; RNA building blocks
n3:klicoveSlovo
n14:Ribosome n14:RNA%20flexibility n14:RNA%20Kink%20Turn n14:RNA%20building%20blocks n14:Molecular%20Dynamics
n3:kodStatuVydavatele
GB - Spojené království Velké Británie a Severního Irska
n3:kontrolniKodProRIV
[52A2098B73D1]
n3:nazevZdroje
Nucleic Acids Research
n3:obor
n16:CF
n3:pocetDomacichTvurcuVysledku
3
n3:pocetTvurcuVysledku
4
n3:projekt
n4:1QS500040581 n4:LC06030 n4:GA203%2F05%2F0388 n4:GA203%2F05%2F0009
n3:rokUplatneniVysledku
n5:2007
n3:svazekPeriodika
35
n3:tvurceVysledku
Koča, Jaroslav Šponer, Jiří Rázga, Filip Mokdad, Ali
n3:zamer
n8:AV0Z50040702 n8:AV0Z50040507 n8:MSM0021622413
s:issn
0305-1048
s:numberOfPages
11
n18:organizacniJednotka
14310