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Statements

Subject Item
n2:RIV%2F00216224%3A14310%2F07%3A00020348%21RIV11-GA0-14310___
rdf:type
skos:Concept n13:Vysledek
dcterms:description
N-heterocyclic analogs of PAHs (N-PAHs) are as well as homocyclic PAHs important and widespread environmental contaminants. Many of them are carcinogens, mutagens and teratogens. Some results indicate that N-PAHs have higher toxic and genotoxic potencies and bioavailability than PAHs. In this study the interference of N-PAHs with retinoid signaling system was tested. After 24 h exposure most of three, four and five ring PAHs and N-PAHs increased RA activity. Obtained data were statistically analyzed and quantitative-structure activity relationship study was performed. This study was supported by GACR 525/05/P160. N-heterocyclic analogs of PAHs (N-PAHs) are as well as homocyclic PAHs important and widespread environmental contaminants. Many of them are carcinogens, mutagens and teratogens. Some results indicate that N-PAHs have higher toxic and genotoxic potencies and bioavailability than PAHs. In this study the interference of N-PAHs with retinoid signaling system was tested. After 24 h exposure most of three, four and five ring PAHs and N-PAHs increased RA activity. Obtained data were statistically analyzed and quantitative-structure activity relationship study was performed. This study was supported by GACR 525/05/P160.
dcterms:title
Interference of N-heterocyclic PAHs with signaling of retinoids Interference of N-heterocyclic PAHs with signaling of retinoids
skos:prefLabel
Interference of N-heterocyclic PAHs with signaling of retinoids Interference of N-heterocyclic PAHs with signaling of retinoids
skos:notation
RIV/00216224:14310/07:00020348!RIV11-GA0-14310___
n3:aktivita
n12:P n12:Z
n3:aktivity
P(GP525/05/P160), Z(MSM0021622412)
n3:dodaniDat
n10:2011
n3:domaciTvurceVysledku
n6:4982800 n6:3738582 n6:6215750 n6:9372318
n3:druhVysledku
n9:O
n3:duvernostUdaju
n16:S
n3:entitaPredkladatele
n14:predkladatel
n3:idSjednocenehoVysledku
427153
n3:idVysledku
RIV/00216224:14310/07:00020348
n3:jazykVysledku
n8:eng
n3:klicovaSlova
retinoid; N-PAHs; in vitro
n3:klicoveSlovo
n7:retinoid n7:N-PAHs n7:in%20vitro
n3:kontrolniKodProRIV
[F944F6260C66]
n3:obor
n5:DN
n3:pocetDomacichTvurcuVysledku
4
n3:pocetTvurcuVysledku
4
n3:projekt
n18:GP525%2F05%2FP160
n3:rokUplatneniVysledku
n10:2007
n3:tvurceVysledku
Pacherník, Jiří Beníšek, Martin Bláha, Luděk Hilscherová, Klára
n3:zamer
n17:MSM0021622412
n11:organizacniJednotka
14310