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Statements

Subject Item
n2:RIV%2F00216224%3A14310%2F07%3A00020344%21RIV10-MSM-14310___
rdf:type
skos:Concept n7:Vysledek
dcterms:description
Humic substances (HS) were for decades regarded as inert in the ecosystems with respect to their possible toxicity. However, HS have been recently shown to elicit various adverse effects generally attributed to xenobiotics. In our study, we used MVLN and H4IIE-luc cell lines stably transfected with luciferase gene under control of estrogen receptor (ER) and Ah receptor (AhR; receptor connected with so-called dioxin-like toxicity) for assessment of anti/estrogenic and AhR-mediated effects of 12 commercially available humic substances. Out of those, five humic acids were shown to induce AhR-mediated activity with relative potencies related to TCDD 2.6 x 10-8-7.4 x 10-8. Organic extracts of HS solutions also elicited high activities what means that lipophilic molecules are responsible for a great part of effect. However, relatively high activity remaining in extracted solution suggests also presence of polar AhR-agonists. Humic substances (HS) were for decades regarded as inert in the ecosystems with respect to their possible toxicity. However, HS have been recently shown to elicit various adverse effects generally attributed to xenobiotics. In our study, we used MVLN and H4IIE-luc cell lines stably transfected with luciferase gene under control of estrogen receptor (ER) and Ah receptor (AhR; receptor connected with so-called dioxin-like toxicity) for assessment of anti/estrogenic and AhR-mediated effects of 12 commercially available humic substances. Out of those, five humic acids were shown to induce AhR-mediated activity with relative potencies related to TCDD 2.6 x 10-8-7.4 x 10-8. Organic extracts of HS solutions also elicited high activities what means that lipophilic molecules are responsible for a great part of effect. However, relatively high activity remaining in extracted solution suggests also presence of polar AhR-agonists.
dcterms:title
AhR-mediated and antiestrogenic activity of humic substances AhR-mediated and antiestrogenic activity of humic substances
skos:prefLabel
AhR-mediated and antiestrogenic activity of humic substances AhR-mediated and antiestrogenic activity of humic substances
skos:notation
RIV/00216224:14310/07:00020344!RIV10-MSM-14310___
n4:aktivita
n16:Z n16:P
n4:aktivity
P(GP525/05/P160), Z(MSM0021622412)
n4:cisloPeriodika
6
n4:dodaniDat
n14:2010
n4:domaciTvurceVysledku
n5:9372318 n5:6120393 n5:4982800 n5:2423685 n5:4468503
n4:druhVysledku
n6:J
n4:duvernostUdaju
n15:S
n4:entitaPredkladatele
n13:predkladatel
n4:idSjednocenehoVysledku
408796
n4:idVysledku
RIV/00216224:14310/07:00020344
n4:jazykVysledku
n8:eng
n4:klicovaSlova
Ah receptor; AhR-mediated activity; Antiestrogenic effects; Endocrine disruption
n4:klicoveSlovo
n12:Endocrine%20disruption n12:Antiestrogenic%20effects n12:AhR-mediated%20activity n12:Ah%20receptor
n4:kodStatuVydavatele
CZ - Česká republika
n4:kontrolniKodProRIV
[D855070859D3]
n4:nazevZdroje
Chemosphere
n4:obor
n18:DN
n4:pocetDomacichTvurcuVysledku
5
n4:pocetTvurcuVysledku
6
n4:projekt
n17:GP525%2F05%2FP160
n4:rokUplatneniVysledku
n14:2007
n4:svazekPeriodika
67
n4:tvurceVysledku
Hilscherová, Klára Holoubek, Ivan Bláha, Luděk Janošek, Jaroslav Giesy, J. P. Bittner, Michal
n4:wos
000245846700005
n4:zamer
n19:MSM0021622412
s:issn
0045-6535
s:numberOfPages
6
n10:organizacniJednotka
14310