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Statements

Subject Item
n2:RIV%2F00216224%3A14310%2F07%3A00020174%21RIV10-MSM-14310___
rdf:type
skos:Concept n19:Vysledek
dcterms:description
A new, simple, rapid, sensitive, and repeatable isocratic reverse-phase HPLC method was developed and validated for simultaneous determination of midazolam and its main three hydroxylated metabolites, i.e. 1' hydroxymidazolam, 4-hydroxymidazolam, and 1',4-dihydroxymidazolam in rat liver perfusate and also plasma. Diazepam was used as an internal standard to ensure precision and accuracy of this method. This method is applicable for modeling and description of possible pharmacological interactions on rat (CYP3A1/2) or human (CYP3A4/5) cytochrome P450 enzymes. A new, simple, rapid, sensitive, and repeatable isocratic reverse-phase HPLC method was developed and validated for simultaneous determination of midazolam and its main three hydroxylated metabolites, i.e. 1' hydroxymidazolam, 4-hydroxymidazolam, and 1',4-dihydroxymidazolam in rat liver perfusate and also plasma. Diazepam was used as an internal standard to ensure precision and accuracy of this method. This method is applicable for modeling and description of possible pharmacological interactions on rat (CYP3A1/2) or human (CYP3A4/5) cytochrome P450 enzymes.
dcterms:title
HPLC determination of midazolam and its three hydroxy metabolites in perfusion medium and plasma from rats HPLC determination of midazolam and its three hydroxy metabolites in perfusion medium and plasma from rats
skos:prefLabel
HPLC determination of midazolam and its three hydroxy metabolites in perfusion medium and plasma from rats HPLC determination of midazolam and its three hydroxy metabolites in perfusion medium and plasma from rats
skos:notation
RIV/00216224:14310/07:00020174!RIV10-MSM-14310___
n3:aktivita
n6:P n6:Z
n3:aktivity
P(GA203/06/0047), P(LC06023), Z(MSM0021622404)
n3:cisloPeriodika
1-2
n3:dodaniDat
n15:2010
n3:domaciTvurceVysledku
n4:5337585 n4:1309137 n4:5235979 n4:5767628 n4:8110549 n4:3648753
n3:druhVysledku
n8:J
n3:duvernostUdaju
n18:S
n3:entitaPredkladatele
n10:predkladatel
n3:idSjednocenehoVysledku
424856
n3:idVysledku
RIV/00216224:14310/07:00020174
n3:jazykVysledku
n14:eng
n3:klicovaSlova
cytochrome P450; midazolam; 1'-hydroxymidazolam; 4-hydroxymidazolam; 1'4-dihydroxymidazolam; rat; perfusion; plasma; HPLC
n3:klicoveSlovo
n7:1%27-hydroxymidazolam n7:1%274-dihydroxymidazolam n7:HPLC n7:plasma n7:midazolam n7:4-hydroxymidazolam n7:rat n7:cytochrome%20P450 n7:perfusion
n3:kodStatuVydavatele
CZ - Česká republika
n3:kontrolniKodProRIV
[70DE282EDBD7]
n3:nazevZdroje
Journal of Chromatography B
n3:obor
n13:CE
n3:pocetDomacichTvurcuVysledku
6
n3:pocetTvurcuVysledku
6
n3:projekt
n16:GA203%2F06%2F0047 n16:LC06023
n3:rokUplatneniVysledku
n15:2007
n3:svazekPeriodika
852
n3:tvurceVysledku
Tomandl, Josef Konečný, Jiří McCaskey Hadašová, Eva Juřica, Jan Dostálek, Miroslav Glatz, Zdeněk
n3:wos
000247286700078
n3:zamer
n17:MSM0021622404
s:issn
1570-0232
s:numberOfPages
7
n5:organizacniJednotka
14310