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Statements

Subject Item
n2:RIV%2F00216224%3A14310%2F07%3A00020104%21RIV10-MSM-14310___
rdf:type
n8:Vysledek skos:Concept
dcterms:description
Acetylcholinesterase (AChE) is a widely spread enzyme playing a very important role in nerve signal transmission. There are several reasons as to why this enzyme is studied, one of them is the treatment of Alzheimers disease. As AChE controls key processes, its inhibition leads to the very fast death of an organism, including humans. However, when this feature is to be used for killing of unwanted organisms (like mosquitoes), one is faced with the question - how much does AChEs differ between species and what are the differences? In this article, the structural point of view was utilized to answer the above questions. The various primary and tertiary alignments show that AChEs are very evolutionary conserved enzymes and this fact leads to difficulties in the search for inhibitors specific for a particular species. Acetylcholinesterase (AChE) is a widely spread enzyme playing a very important role in nerve signal transmission. There are several reasons as to why this enzyme is studied, one of them is the treatment of Alzheimers disease. As AChE controls key processes, its inhibition leads to the very fast death of an organism, including humans. However, when this feature is to be used for killing of unwanted organisms (like mosquitoes), one is faced with the question - how much does AChEs differ between species and what are the differences? In this article, the structural point of view was utilized to answer the above questions. The various primary and tertiary alignments show that AChEs are very evolutionary conserved enzymes and this fact leads to difficulties in the search for inhibitors specific for a particular species.
dcterms:title
Acetylcholinesterases - the similarities and differences Acetylcholinesterases - the similarities and differences
skos:prefLabel
Acetylcholinesterases - the similarities and differences Acetylcholinesterases - the similarities and differences
skos:notation
RIV/00216224:14310/07:00020104!RIV10-MSM-14310___
n4:aktivita
n5:P n5:Z
n4:aktivity
P(GD204/03/H016), P(LC06030), Z(MSM0021622413)
n4:cisloPeriodika
4
n4:dodaniDat
n14:2010
n4:domaciTvurceVysledku
n7:9309616 n7:4347374 n7:9762132
n4:druhVysledku
n17:J
n4:duvernostUdaju
n9:S
n4:entitaPredkladatele
n15:predkladatel
n4:idSjednocenehoVysledku
408412
n4:idVysledku
RIV/00216224:14310/07:00020104
n4:jazykVysledku
n16:eng
n4:klicovaSlova
computational chemistry; computer modeling; acetycholinesterase; AChE; species; alignment
n4:klicoveSlovo
n13:computational%20chemistry n13:acetycholinesterase n13:computer%20modeling n13:alignment n13:AChE n13:species
n4:kodStatuVydavatele
CZ - Česká republika
n4:kontrolniKodProRIV
[9384576B99B0]
n4:nazevZdroje
Journal of Enzyme Inhibition and Medicinal Chemistry
n4:obor
n6:CF
n4:pocetDomacichTvurcuVysledku
3
n4:pocetTvurcuVysledku
5
n4:projekt
n12:LC06030 n12:GD204%2F03%2FH016
n4:rokUplatneniVysledku
n14:2007
n4:svazekPeriodika
22
n4:tvurceVysledku
Kuča, Kamil Koča, Jaroslav Wiesner, Jiří Jun, Daniel Kříž, Zdeněk
n4:zamer
n18:MSM0021622413
s:issn
1475-6366
s:numberOfPages
8
n19:organizacniJednotka
14310