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Statements

Subject Item
n2:RIV%2F00216224%3A14310%2F07%3A00020085%21RIV10-MSM-14310___
rdf:type
skos:Concept n19:Vysledek
dcterms:description
v-myb-oncogene of avian myeloblastosis virus transforms myelomonocytic cells in vitro and induces acute monoblastic leukemia in vivo. The transforming effect of the v-myb can be suppressed using phorbol ester (TPA) or histone deacetylase inhibitor trichostatin A (TSA), the inducers of cell differentiation that are in clinical trials. In this study, we used proteomics-based approach to identify proteins with variable expression in differentiated BM2 cells. Proteome variations induced by TPA and TSA were compared to examine the mechanism of differentiation-promoting effects of these drugs. We found that expression of several proteins participating in cell cytoskeleton rearrangement, heat shock response, proteosynthesis and cell signaling was altered in TPA- or TSA-treated cells. We present here the first comparative proteome analysis of v-myb-transformed monoblasts BM2 focused on identification of proteins involved in their terminal differentiation. v-myb-oncogene of avian myeloblastosis virus transforms myelomonocytic cells in vitro and induces acute monoblastic leukemia in vivo. The transforming effect of the v-myb can be suppressed using phorbol ester (TPA) or histone deacetylase inhibitor trichostatin A (TSA), the inducers of cell differentiation that are in clinical trials. In this study, we used proteomics-based approach to identify proteins with variable expression in differentiated BM2 cells. Proteome variations induced by TPA and TSA were compared to examine the mechanism of differentiation-promoting effects of these drugs. We found that expression of several proteins participating in cell cytoskeleton rearrangement, heat shock response, proteosynthesis and cell signaling was altered in TPA- or TSA-treated cells. We present here the first comparative proteome analysis of v-myb-transformed monoblasts BM2 focused on identification of proteins involved in their terminal differentiation.
dcterms:title
A proteomic analysis of protein variations during differentiation of v-myb-transformed monoblasts A proteomic analysis of protein variations during differentiation of v-myb-transformed monoblasts
skos:prefLabel
A proteomic analysis of protein variations during differentiation of v-myb-transformed monoblasts A proteomic analysis of protein variations during differentiation of v-myb-transformed monoblasts
skos:notation
RIV/00216224:14310/07:00020085!RIV10-MSM-14310___
n3:aktivita
n14:P n14:Z
n3:aktivity
P(GA301/03/1055), P(GA301/06/0036), P(GP301/03/D022), Z(MSM0021622415)
n3:cisloPeriodika
2
n3:dodaniDat
n11:2010
n3:domaciTvurceVysledku
n8:4568567 n8:5687683 n8:6234348 n8:9091211 n8:6659446 n8:9725741 n8:9039058
n3:druhVysledku
n10:J
n3:duvernostUdaju
n5:S
n3:entitaPredkladatele
n18:predkladatel
n3:idSjednocenehoVysledku
408122
n3:idVysledku
RIV/00216224:14310/07:00020085
n3:jazykVysledku
n15:eng
n3:klicovaSlova
v-myb; monoblast; macrophage; differentiation; proteome; two-dimensional gel electrophoresis; trichostatin A; TPA; mass spectrometry
n3:klicoveSlovo
n4:differentiation n4:trichostatin%20A n4:mass%20spectrometry n4:proteome n4:macrophage n4:two-dimensional%20gel%20electrophoresis n4:v-myb n4:monoblast n4:TPA
n3:kodStatuVydavatele
US - Spojené státy americké
n3:kontrolniKodProRIV
[3175217B7FCA]
n3:nazevZdroje
Leukemia Research
n3:obor
n7:EB
n3:pocetDomacichTvurcuVysledku
7
n3:pocetTvurcuVysledku
7
n3:projekt
n9:GA301%2F06%2F0036 n9:GA301%2F03%2F1055 n9:GP301%2F03%2FD022
n3:rokUplatneniVysledku
n11:2007
n3:svazekPeriodika
31
n3:tvurceVysledku
Beneš, Petr Ondroušková, Eva Konečná, Hana Šmarda, Jan Váňa, Petr Černá, Karolína Zdráhal, Zbyněk
n3:zamer
n17:MSM0021622415
s:issn
0145-2126
s:numberOfPages
9
n13:organizacniJednotka
14310