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Statements

Subject Item
n2:RIV%2F00216224%3A14310%2F06%3A00064401%21RIV13-MSM-14310___
rdf:type
skos:Concept n6:Vysledek
rdfs:seeAlso
http://www.nature.com/leu/journal/v20/n6/full/2404202a.html
dcterms:description
Fibroblast growth factor receptor 3 (FGFR3) is a membrane-anchored receptor tyrosine kinase that transmits intercellular signals mediated by a family of fibroblast growth factors (FGFs). In multiple myeloma (MM), 15% of patients markedly upregulate FGFR3 as a consequence of a t(4;14)(p16.3;q32) translocation. Ectopic expression of FGFR3 enhances MM cell proliferation and survival, demonstrating the oncogenic potential of FGFR3. Fibroblast growth factor receptor 3 (FGFR3) is a membrane-anchored receptor tyrosine kinase that transmits intercellular signals mediated by a family of fibroblast growth factors (FGFs). In multiple myeloma (MM), 15% of patients markedly upregulate FGFR3 as a consequence of a t(4;14)(p16.3;q32) translocation. Ectopic expression of FGFR3 enhances MM cell proliferation and survival, demonstrating the oncogenic potential of FGFR3.
dcterms:title
The fibroblast growth factors in multiple myeloma The fibroblast growth factors in multiple myeloma
skos:prefLabel
The fibroblast growth factors in multiple myeloma The fibroblast growth factors in multiple myeloma
skos:notation
RIV/00216224:14310/06:00064401!RIV13-MSM-14310___
n4:aktivita
n19:I
n4:aktivity
I
n4:cisloPeriodika
6
n4:dodaniDat
n5:2013
n4:domaciTvurceVysledku
n14:5512646
n4:druhVysledku
n18:J
n4:duvernostUdaju
n15:S
n4:entitaPredkladatele
n12:predkladatel
n4:idSjednocenehoVysledku
475766
n4:idVysledku
RIV/00216224:14310/06:00064401
n4:jazykVysledku
n11:eng
n4:klicovaSlova
FACTOR RECEPTOR-3; EXPRESSION; MUTATIONS
n4:klicoveSlovo
n9:MUTATIONS n9:FACTOR%20RECEPTOR-3 n9:EXPRESSION
n4:kodStatuVydavatele
GB - Spojené království Velké Británie a Severního Irska
n4:kontrolniKodProRIV
[6E64E496FACA]
n4:nazevZdroje
Leukemia
n4:obor
n10:ED
n4:pocetDomacichTvurcuVysledku
1
n4:pocetTvurcuVysledku
3
n4:rokUplatneniVysledku
n5:2006
n4:svazekPeriodika
20
n4:tvurceVysledku
Krejčí, Pavel Mekikian, PB Wilcox, WR
n4:wos
000237806500038
s:issn
0887-6924
s:numberOfPages
4
n16:doi
10.1038/sj.leu.2404202
n13:organizacniJednotka
14310