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Statements

Subject Item
n2:RIV%2F00216224%3A14310%2F06%3A00032342%21RIV10-MSM-14310___
rdf:type
n15:Vysledek skos:Concept
dcterms:description
Bound to have similarities: Although the overall shape of discodermolide bound to tubulin resembles the structure of the free ligand, the precise conformation and orientation of the lactone ring are different. A partially overlapping pharmacophore model supported by protein-mediated interligand NOE signals is proposed to explain the similar (but not fully equivalent) biological activity of discodermolide and epothilone A. Bound to have similarities: Although the overall shape of discodermolide bound to tubulin resembles the structure of the free ligand, the precise conformation and orientation of the lactone ring are different. A partially overlapping pharmacophore model supported by protein-mediated interligand NOE signals is proposed to explain the similar (but not fully equivalent) biological activity of discodermolide and epothilone A.
dcterms:title
The tubulin-bound conformation of discodermolide derived by NMR studies in solution supports a common pharmacophore model for epothilone and discodermolide The tubulin-bound conformation of discodermolide derived by NMR studies in solution supports a common pharmacophore model for epothilone and discodermolide
skos:prefLabel
The tubulin-bound conformation of discodermolide derived by NMR studies in solution supports a common pharmacophore model for epothilone and discodermolide The tubulin-bound conformation of discodermolide derived by NMR studies in solution supports a common pharmacophore model for epothilone and discodermolide
skos:notation
RIV/00216224:14310/06:00032342!RIV10-MSM-14310___
n3:aktivita
n16:V
n3:aktivity
V
n3:cisloPeriodika
44
n3:dodaniDat
n9:2010
n3:domaciTvurceVysledku
n12:7878788
n3:druhVysledku
n8:J
n3:duvernostUdaju
n11:S
n3:entitaPredkladatele
n13:predkladatel
n3:idSjednocenehoVysledku
504522
n3:idVysledku
RIV/00216224:14310/06:00032342
n3:jazykVysledku
n17:eng
n3:klicovaSlova
conformation analysis; discodermolide; NMR spectroscopy; structure-activity relationships; tubulin
n3:klicoveSlovo
n4:structure-activity%20relationships n4:discodermolide n4:NMR%20spectroscopy n4:tubulin n4:conformation%20analysis
n3:kodStatuVydavatele
DE - Spolková republika Německo
n3:kontrolniKodProRIV
[FA9EA57533FF]
n3:nazevZdroje
Angewandte Chemie International Edition
n3:obor
n10:BO
n3:pocetDomacichTvurcuVysledku
1
n3:pocetTvurcuVysledku
6
n3:rokUplatneniVysledku
n9:2006
n3:svazekPeriodika
45
n3:tvurceVysledku
Paterson, Ian Meiler, Jens Kubíček, Karel Carlomagno, Teresa Lyothier, Isabelle Sanchez-Pedregal, Victor M
s:issn
1433-7851
s:numberOfPages
7
n7:organizacniJednotka
14310