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Statements

Subject Item
n2:RIV%2F00216224%3A14310%2F06%3A00025786%21RIV10-MSM-14310___
rdf:type
skos:Concept n14:Vysledek
dcterms:description
Authors conducted a one-year prospective study to determine whether CHOP regimen (cyclophosphamide, doxorubicin, vincristin, and prednisone), used in the treatment of aggressive non-Hodgkin's lymphoma, is associated with the presence of an early impairment of cardiac function. Forty seven patients were prospectively examined (27 male and 20 female) aged 49 +/- 14 years who were treated with CHOP regimen. Rest echocardiography was performed at baseline and one-year control. Cardiopulmonary exercise test was carried out at one-year control examination. The ejection fraction (EF), parameters of diastolic function, myocardial performance index (MPI), and pVO(2) were used as parameters of cardiopulmonary performance. The cumulative dose (CD) of doxorubicin was 277 +/- 56 (300 mg/m(2)) was given. The baseline EF 64 +/- 5% (64%) decreased to 58 +/- 7% (57%) at the one-year control (p<0.0001). 23% of patients exhibited a drop in EF >10% during the follow-up. Authors conducted a one-year prospective study to determine whether CHOP regimen (cyclophosphamide, doxorubicin, vincristin, and prednisone), used in the treatment of aggressive non-Hodgkin's lymphoma, is associated with the presence of an early impairment of cardiac function. Forty seven patients were prospectively examined (27 male and 20 female) aged 49 +/- 14 years who were treated with CHOP regimen. Rest echocardiography was performed at baseline and one-year control. Cardiopulmonary exercise test was carried out at one-year control examination. The ejection fraction (EF), parameters of diastolic function, myocardial performance index (MPI), and pVO(2) were used as parameters of cardiopulmonary performance. The cumulative dose (CD) of doxorubicin was 277 +/- 56 (300 mg/m(2)) was given. The baseline EF 64 +/- 5% (64%) decreased to 58 +/- 7% (57%) at the one-year control (p<0.0001). 23% of patients exhibited a drop in EF >10% during the follow-up.
dcterms:title
Cardiac function and cardiopulmonary performance in patients after treatment for non-Hodgkin's lymphoma Cardiac function and cardiopulmonary performance in patients after treatment for non-Hodgkin's lymphoma
skos:prefLabel
Cardiac function and cardiopulmonary performance in patients after treatment for non-Hodgkin's lymphoma Cardiac function and cardiopulmonary performance in patients after treatment for non-Hodgkin's lymphoma
skos:notation
RIV/00216224:14310/06:00025786!RIV10-MSM-14310___
n3:aktivita
n11:P
n3:aktivity
P(LC06024)
n3:cisloPeriodika
2
n3:dodaniDat
n16:2010
n3:domaciTvurceVysledku
n4:9566570 n4:9640444 n4:9890009 n4:7712960 n4:2927551 n4:1906232 n4:6166202
n3:druhVysledku
n6:J
n3:duvernostUdaju
n17:S
n3:entitaPredkladatele
n9:predkladatel
n3:idSjednocenehoVysledku
467777
n3:idVysledku
RIV/00216224:14310/06:00025786
n3:jazykVysledku
n15:eng
n3:klicovaSlova
cardiotoxicity; doxorubicin; non-Hodgkin's lymphoma
n3:klicoveSlovo
n8:doxorubicin n8:non-Hodgkin%27s%20lymphoma n8:cardiotoxicity
n3:kodStatuVydavatele
SK - Slovenská republika
n3:kontrolniKodProRIV
[6836F42ED170]
n3:nazevZdroje
Neoplasma
n3:obor
n18:FD
n3:pocetDomacichTvurcuVysledku
7
n3:pocetTvurcuVysledku
7
n3:projekt
n12:LC06024
n3:rokUplatneniVysledku
n16:2006
n3:svazekPeriodika
53
n3:tvurceVysledku
Pospíšil, Zdeněk Elbl, Lubomír Tomášková, Iva Vášová, Ingrid Navrátil, Milan Vorlíček, Jiří Jedlička, František
n3:wos
000236399400014
s:issn
0028-2685
s:numberOfPages
8
n13:organizacniJednotka
14310