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Statements

Subject Item
n2:RIV%2F00216224%3A14310%2F06%3A00017836%21RIV10-MSM-14310___
rdf:type
n12:Vysledek skos:Concept
dcterms:description
Pediatric tumors are the second main cause of childrens death in developed countries. Contrary to leukemias chromosomal alterations associated with malignant transformations are less well characterized for pediatric solid tumors. We present results of cytogenetic examinations of 262 pediatric solid tumors. Some of them were examined using by interphase fluorescent in situ hybridization (I-FISH), especially tumors where deletions or amplifications of specific genes and/or presence of fusion genes are known and could be used as diagnostic tool. Proven prognostic significance of the n-myc amplification, del 1p36, gain 17q, abnormalities on chromosome 11 are well known for children with neuroblastoma. For medulloblastomas i(17p), c-myc and i(12p) in germinal tumors are the other candidates. Vast majority of tumor samples were cultured and other possible chromosomal abnormalities were detected using FISH, spectral karyotyping (SKY) and comparative genomic hybridization (CGH). Pediatric tumors are the second main cause of childrens death in developed countries. Contrary to leukemias chromosomal alterations associated with malignant transformations are less well characterized for pediatric solid tumors. We present results of cytogenetic examinations of 262 pediatric solid tumors. Some of them were examined using by interphase fluorescent in situ hybridization (I-FISH), especially tumors where deletions or amplifications of specific genes and/or presence of fusion genes are known and could be used as diagnostic tool. Proven prognostic significance of the n-myc amplification, del 1p36, gain 17q, abnormalities on chromosome 11 are well known for children with neuroblastoma. For medulloblastomas i(17p), c-myc and i(12p) in germinal tumors are the other candidates. Vast majority of tumor samples were cultured and other possible chromosomal abnormalities were detected using FISH, spectral karyotyping (SKY) and comparative genomic hybridization (CGH).
dcterms:title
Detection of chromosomal aberrations by FISH, CGH and SKY in cultured and noncultured tumours in children during 2003 and 2005 Detection of chromosomal aberrations by FISH, CGH and SKY in cultured and noncultured tumours in children during 2003 and 2005
skos:prefLabel
Detection of chromosomal aberrations by FISH, CGH and SKY in cultured and noncultured tumours in children during 2003 and 2005 Detection of chromosomal aberrations by FISH, CGH and SKY in cultured and noncultured tumours in children during 2003 and 2005
skos:notation
RIV/00216224:14310/06:00017836!RIV10-MSM-14310___
n4:aktivita
n14:Z
n4:aktivity
Z(MSM0021622415)
n4:dodaniDat
n11:2010
n4:domaciTvurceVysledku
n10:7688776 n10:1398954 n10:6933300 n10:5283752 n10:9243682 n10:8611173
n4:druhVysledku
n21:D
n4:duvernostUdaju
n13:S
n4:entitaPredkladatele
n15:predkladatel
n4:idSjednocenehoVysledku
471010
n4:idVysledku
RIV/00216224:14310/06:00017836
n4:jazykVysledku
n20:eng
n4:klicovaSlova
Chromosomal aberrations; solid tumours in children; FISH; CGH; SKY
n4:klicoveSlovo
n6:SKY n6:FISH n6:solid%20tumours%20in%20children n6:CGH n6:Chromosomal%20aberrations
n4:kontrolniKodProRIV
[809BCC9358A3]
n4:mistoKonaniAkce
Amsterdam
n4:mistoVydani
Amsterdam
n4:nazevZdroje
Europen Journal of Human Genetics
n4:obor
n8:EB
n4:pocetDomacichTvurcuVysledku
6
n4:pocetTvurcuVysledku
8
n4:rokUplatneniVysledku
n11:2006
n4:tvurceVysledku
Múdry, Peter Oltová, Alexandra Kuglík, Petr Štěrba, Jaroslav Žežulková, Dita Vranová, Vladimíra Baičiová, Věra Šmuhařová, Petra
n4:typAkce
n17:EUR
n4:zahajeniAkce
2006-01-01+01:00
n4:zamer
n7:MSM0021622415
s:numberOfPages
1
n16:hasPublisher
ESHG
n5:isbn
80-7232-264-8
n19:organizacniJednotka
14310