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Statements

Subject Item
n2:RIV%2F00216224%3A14310%2F06%3A00017436%21RIV10-MZ0-14310___
rdf:type
skos:Concept n12:Vysledek
dcterms:description
Attention deficit hyperactivity disorder (ADHD) is a multifactorial disorder with significant genetic contribution. Dopamine genes have been the initial candidates based on the site of the action of the psychostimulant drugs. The other genes from neurotransmitter and immune system are in focus too. We have investigated whether there is an association between ADHD and polymorphisms of 13 candidate genes: DAT1, DRD2, COMT, MAOB, ACE, ANG, CCR5, BDNF, MU, IL-2, IL-6, TNF-alpha, and M235T. The aim of our case-control study was to determine whether the ADHD boys (118) have different genotype and alelic frequencies of examined polymorphisms of the above mentioned genes compared to controls (153). No significant differences were found between groups of boys in allelic and genotype frequencies of COMT, MAOB, ACE, ANG, CCR5, BDNF, MU, IL-2, IL-6, TNF-alpha and M235T genes (p < 0.05). Attention deficit hyperactivity disorder (ADHD) is a multifactorial disorder with significant genetic contribution. Dopamine genes have been the initial candidates based on the site of the action of the psychostimulant drugs. The other genes from neurotransmitter and immune system are in focus too. We have investigated whether there is an association between ADHD and polymorphisms of 13 candidate genes: DAT1, DRD2, COMT, MAOB, ACE, ANG, CCR5, BDNF, MU, IL-2, IL-6, TNF-alpha, and M235T. The aim of our case-control study was to determine whether the ADHD boys (118) have different genotype and alelic frequencies of examined polymorphisms of the above mentioned genes compared to controls (153). No significant differences were found between groups of boys in allelic and genotype frequencies of COMT, MAOB, ACE, ANG, CCR5, BDNF, MU, IL-2, IL-6, TNF-alpha and M235T genes (p < 0.05).
dcterms:title
A case-control study of the relationship between 13 candidate genes and ADHD A case-control study of the relationship between 13 candidate genes and ADHD
skos:prefLabel
A case-control study of the relationship between 13 candidate genes and ADHD A case-control study of the relationship between 13 candidate genes and ADHD
skos:notation
RIV/00216224:14310/06:00017436!RIV10-MZ0-14310___
n4:aktivita
n15:P n15:Z
n4:aktivity
P(NR8137), Z(MSM0021622413)
n4:cisloPeriodika
7
n4:dodaniDat
n18:2010
n4:domaciTvurceVysledku
n5:8929998 n5:9217088 n5:9713050 n5:8989087 n5:9796428 n5:3881652 n5:9480919
n4:druhVysledku
n16:J
n4:duvernostUdaju
n19:S
n4:entitaPredkladatele
n13:predkladatel
n4:idSjednocenehoVysledku
463425
n4:idVysledku
RIV/00216224:14310/06:00017436
n4:jazykVysledku
n11:eng
n4:klicovaSlova
ADHD; polymorphism; DAT1; DRD2; COMT; MAOB; ACE; ANG; CCR5; BDNF; MU; IL-2; IL-6; TNF; M235T
n4:klicoveSlovo
n7:DRD2 n7:COMT n7:DAT1 n7:MU n7:ACE n7:M235T n7:CCR5 n7:ANG n7:BDNF n7:polymorphism n7:IL-2 n7:ADHD n7:IL-6 n7:MAOB n7:TNF
n4:kodStatuVydavatele
CZ - Česká republika
n4:kontrolniKodProRIV
[3ED23D33EE6E]
n4:nazevZdroje
American Journal of Medical Genetics
n4:obor
n17:FH
n4:pocetDomacichTvurcuVysledku
7
n4:pocetTvurcuVysledku
7
n4:projekt
n8:NR8137
n4:rokUplatneniVysledku
n18:2006
n4:svazekPeriodika
141B
n4:tvurceVysledku
Mikeš, Vladimír Štaif, Radim Pitelová, Renáta Theiner, Pavel Drtílková, Ivana Šerý, Omar Lochman, Jan
n4:zamer
n9:MSM0021622413
s:issn
1552-4841
s:numberOfPages
2
n10:organizacniJednotka
14310