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Statements

Subject Item
n2:RIV%2F00216224%3A14310%2F06%3A00017097%21RIV10-MSM-14310___
rdf:type
skos:Concept n15:Vysledek
dcterms:description
Combining explicit-solvent molecular dynamics simulation and single molecule fluorescence spectroscopy approaches, we find that a ribozyme from a subviral plant pathogen exhibits a coupled hydrogen bonding network that communicates dynamic structural rearrangements throughout the catalytic core in response to site-specific chemical modification. Trapped long-residency water molecules are critical for this network. Combining explicit-solvent molecular dynamics simulation and single molecule fluorescence spectroscopy approaches, we find that a ribozyme from a subviral plant pathogen exhibits a coupled hydrogen bonding network that communicates dynamic structural rearrangements throughout the catalytic core in response to site-specific chemical modification. Trapped long-residency water molecules are critical for this network.
dcterms:title
Trapped water molecules are essential to structural dynamics and function of a ribozyme Trapped water molecules are essential to structural dynamics and function of a ribozyme
skos:prefLabel
Trapped water molecules are essential to structural dynamics and function of a ribozyme Trapped water molecules are essential to structural dynamics and function of a ribozyme
skos:notation
RIV/00216224:14310/06:00017097!RIV10-MSM-14310___
n3:aktivita
n9:Z n9:P
n3:aktivity
P(1QS500040581), P(GA203/05/0009), P(GA203/05/0388), P(LC06030), P(LC512), Z(AV0Z40550506), Z(AV0Z50040507), Z(MSM0021622413)
n3:cisloPeriodika
36
n3:dodaniDat
n12:2010
n3:domaciTvurceVysledku
n8:3223779 n8:9031510
n3:druhVysledku
n16:J
n3:duvernostUdaju
n7:S
n3:entitaPredkladatele
n19:predkladatel
n3:idSjednocenehoVysledku
504308
n3:idVysledku
RIV/00216224:14310/06:00017097
n3:jazykVysledku
n18:eng
n3:klicovaSlova
coupled molecular motions; hairpin ribozyme; molecular dynamics; proton wire
n3:klicoveSlovo
n6:coupled%20molecular%20motions n6:hairpin%20ribozyme n6:proton%20wire n6:molecular%20dynamics
n3:kodStatuVydavatele
CZ - Česká republika
n3:kontrolniKodProRIV
[F15723AE749A]
n3:nazevZdroje
The Proceedings of the National Academy of Sciences
n3:obor
n14:BO
n3:pocetDomacichTvurcuVysledku
2
n3:pocetTvurcuVysledku
4
n3:projekt
n4:GA203%2F05%2F0009 n4:LC512 n4:LC06030 n4:GA203%2F05%2F0388 n4:1QS500040581
n3:rokUplatneniVysledku
n12:2006
n3:svazekPeriodika
103
n3:tvurceVysledku
Šponer, Jiří Nils, Walter Réblová, Kamila Rhodes, Maria
n3:zamer
n13:MSM0021622413 n13:AV0Z50040507 n13:AV0Z40550506
s:issn
1091-6490
s:numberOfPages
6
n17:organizacniJednotka
14310