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Statements

Subject Item
n2:RIV%2F00216224%3A14310%2F06%3A00016826%21RIV10-MSM-14310___
rdf:type
n3:Vysledek skos:Concept
dcterms:description
Long range scalar 5J(H1',F) couplings were observed in 5-fluoropyrimidine substituted RNA. We developed a novel S3E-19F-alfa/beta-edited NOESY experiment for quantitation of these long range scalar 5J(H1',F), where the J-couplings can be extracted from inspection of intraresidual (H1',H6) NOE crosspeaks. The 5J(H1',F) couplings can be used to restrict the glycosidic torsion angle which defines the orientation of the base with respect to the ribose sugar moiety. Quantum chemical calculations were exploited to investigate the relation between scalar couplings and conformations around the glycosidic bond in oligonucleotides. The theoretical dependence of the observed 5J(H1',F) couplings on the torsion angle Ó can be described by a generalized Karplus relationship. The corresponding density functional theory (DFT) analysis is outlined. Long range scalar 5J(H1',F) couplings were observed in 5-fluoropyrimidine substituted RNA. We developed a novel S3E-19F-alfa/beta-edited NOESY experiment for quantitation of these long range scalar 5J(H1',F), where the J-couplings can be extracted from inspection of intraresidual (H1',H6) NOE crosspeaks. The 5J(H1',F) couplings can be used to restrict the glycosidic torsion angle which defines the orientation of the base with respect to the ribose sugar moiety. Quantum chemical calculations were exploited to investigate the relation between scalar couplings and conformations around the glycosidic bond in oligonucleotides. The theoretical dependence of the observed 5J(H1',F) couplings on the torsion angle Ó can be described by a generalized Karplus relationship. The corresponding density functional theory (DFT) analysis is outlined.
dcterms:title
Measurement of Long Range 1H-19F Scalar Coupling Constants and their Glycosidic Torsion Dependence in 5-Fluoropyrimidine Substituted RNA. Measurement of Long Range 1H-19F Scalar Coupling Constants and their Glycosidic Torsion Dependence in 5-Fluoropyrimidine Substituted RNA.
skos:prefLabel
Measurement of Long Range 1H-19F Scalar Coupling Constants and their Glycosidic Torsion Dependence in 5-Fluoropyrimidine Substituted RNA. Measurement of Long Range 1H-19F Scalar Coupling Constants and their Glycosidic Torsion Dependence in 5-Fluoropyrimidine Substituted RNA.
skos:notation
RIV/00216224:14310/06:00016826!RIV10-MSM-14310___
n4:aktivita
n15:Z
n4:aktivity
Z(MSM0021622413)
n4:cisloPeriodika
17
n4:dodaniDat
n18:2010
n4:domaciTvurceVysledku
n7:1962604 n7:3906884
n4:druhVysledku
n12:J
n4:duvernostUdaju
n16:S
n4:entitaPredkladatele
n17:predkladatel
n4:idSjednocenehoVysledku
484543
n4:idVysledku
RIV/00216224:14310/06:00016826
n4:jazykVysledku
n5:eng
n4:klicovaSlova
Scalar Coupling Constants; Fluorine; 5-Fluorouridine; 5-Fluorocytidine; HIV-TAR RNA
n4:klicoveSlovo
n8:HIV-TAR%20RNA n8:5-Fluorocytidine n8:5-Fluorouridine n8:Scalar%20Coupling%20Constants n8:Fluorine
n4:kodStatuVydavatele
CZ - Česká republika
n4:kontrolniKodProRIV
[BC3607F5AC8B]
n4:nazevZdroje
Journal of the American Chemical Society
n4:obor
n6:CF
n4:pocetDomacichTvurcuVysledku
2
n4:pocetTvurcuVysledku
6
n4:rokUplatneniVysledku
n18:2006
n4:svazekPeriodika
128
n4:tvurceVysledku
Sklenář, Vladimír Munzarová, Markéta Williamson, James R. Bermel, Wolfgang Hennig, Mirko Scott, Lincol G.
n4:zamer
n14:MSM0021622413
s:issn
0002-7863
s:numberOfPages
8
n10:organizacniJednotka
14310