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Statements

Subject Item
n2:RIV%2F00216224%3A14310%2F06%3A00016583%21RIV10-MZ0-14310___
rdf:type
skos:Concept n18:Vysledek
dcterms:description
Objectives: Attention deficit hyperactivity disorder (ADHD) is a prevalent childhood disorder. Evidence from the family and twin studies suggest that ADHD is familiar and highly heritable. Association studies are frequently used for the searching of markers responsible for genetic basis of ADHD. We investigated TaqI polymorphism of the dopamine receptor D2 (DRD2) in relationship with ADHD. The association between TaqI A polymorphism of DRD2 gene and ADHD has previously been published. Design: We used the association study to test the relationship between TaqI A polymorphism of DRD2 gene and ADHD on groups of ADHD boys and control boys. Setting: For DNA isolation, buccal tissue was used. PCR with restriction analysis of PCR products was used for genotyping. Results: We found statistically different genotypic and allelic frequencies (p < 0,008, p < 0,002, respectively) of DRD2 polymorphism between two studied groups of boys. Objectives: Attention deficit hyperactivity disorder (ADHD) is a prevalent childhood disorder. Evidence from the family and twin studies suggest that ADHD is familiar and highly heritable. Association studies are frequently used for the searching of markers responsible for genetic basis of ADHD. We investigated TaqI polymorphism of the dopamine receptor D2 (DRD2) in relationship with ADHD. The association between TaqI A polymorphism of DRD2 gene and ADHD has previously been published. Design: We used the association study to test the relationship between TaqI A polymorphism of DRD2 gene and ADHD on groups of ADHD boys and control boys. Setting: For DNA isolation, buccal tissue was used. PCR with restriction analysis of PCR products was used for genotyping. Results: We found statistically different genotypic and allelic frequencies (p < 0,008, p < 0,002, respectively) of DRD2 polymorphism between two studied groups of boys. Objectives: Attention deficit hyperactivity disorder (ADHD) is a prevalent childhood disorder. Evidence from the family and twin studies suggest that ADHD is familiar and highly heritable. Association studies are frequently used for the searching of markers responsible for genetic basis of ADHD. We investigated TaqI polymorphism of the dopamine receptor D2 (DRD2) in relationship with ADHD. The association between TaqI A polymorphism of DRD2 gene and ADHD has previously been published. Design: We used the association study to test the relationship between TaqI A polymorphism of DRD2 gene and ADHD on groups of ADHD boys and control boys. Setting: For DNA isolation, buccal tissue was used. PCR with restriction analysis of PCR products was used for genotyping. Results: We found statistically different genotypic and allelic frequencies (p < 0,008, p < 0,002, respectively) of DRD2 polymorphism between two studied groups of boys.
dcterms:title
Polymorphism of DRD2 gene and ADHD Polymorphism of DRD2 gene and ADHD Polymorphism of DRD2 gene and ADHD
skos:prefLabel
Polymorphism of DRD2 gene and ADHD Polymorphism of DRD2 gene and ADHD Polymorphism of DRD2 gene and ADHD
skos:notation
RIV/00216224:14310/06:00016583!RIV10-MZ0-14310___
n3:aktivita
n8:Z n8:P
n3:aktivity
P(NF6520), Z(MSM0021622413)
n3:cisloPeriodika
1
n3:dodaniDat
n11:2010
n3:domaciTvurceVysledku
n7:3881652 n7:8989087 n7:9480919 n7:9713050 n7:9796428 n7:8430322 n7:8929998
n3:druhVysledku
n12:J
n3:duvernostUdaju
n6:S
n3:entitaPredkladatele
n17:predkladatel
n3:idSjednocenehoVysledku
492880
n3:idVysledku
RIV/00216224:14310/06:00016583
n3:jazykVysledku
n19:cze
n3:klicovaSlova
ADHD; dopamine; DRD2; polymorphism; association; gene
n3:klicoveSlovo
n4:dopamine n4:DRD2 n4:ADHD n4:polymorphism n4:gene n4:association
n3:kodStatuVydavatele
CZ - Česká republika
n3:kontrolniKodProRIV
[DF2423FC49FF]
n3:nazevZdroje
Neuroendocrinology Letters
n3:obor
n16:FL
n3:pocetDomacichTvurcuVysledku
7
n3:pocetTvurcuVysledku
7
n3:projekt
n13:NF6520
n3:rokUplatneniVysledku
n11:2006
n3:svazekPeriodika
27
n3:tvurceVysledku
Štaif, Radim Šerý, Omar Lochman, Jan Znojil, Vladimír Drtílková, Ivana Pitelová, Renáta Theiner, Pavel
n3:zamer
n14:MSM0021622413
s:issn
0172-780X
s:numberOfPages
5
n15:organizacniJednotka
14310