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Statements

Subject Item
n2:RIV%2F00216224%3A14310%2F06%3A00016118%21RIV10-MSM-14310___
rdf:type
skos:Concept n11:Vysledek
dcterms:description
Healthy cells strictly regulate gene transcription to control crucial cellular regulatory pathways. Members of the Jun protein family, c-Jun, JunB, and JunD are key subunits of the transcription factor AP-1 that controls transcription from various gene promoters. The genes targeted by Jun affect essential life processes, such as cell cycle progression, differentiation or programmed cell death. Therefore, the loss of proper Jun function is often associated with cancer. This review summarizes recent advances in understanding of function of the Jun proteins in healthy and cancer cells. Healthy cells strictly regulate gene transcription to control crucial cellular regulatory pathways. Members of the Jun protein family, c-Jun, JunB, and JunD are key subunits of the transcription factor AP-1 that controls transcription from various gene promoters. The genes targeted by Jun affect essential life processes, such as cell cycle progression, differentiation or programmed cell death. Therefore, the loss of proper Jun function is often associated with cancer. This review summarizes recent advances in understanding of function of the Jun proteins in healthy and cancer cells.
dcterms:title
Jun: the master regulator in healthy and cancer cells Jun: the master regulator in healthy and cancer cells
skos:prefLabel
Jun: the master regulator in healthy and cancer cells Jun: the master regulator in healthy and cancer cells
skos:notation
RIV/00216224:14310/06:00016118!RIV10-MSM-14310___
n3:aktivita
n10:P n10:Z
n3:aktivity
P(GA301/06/0036), Z(MSM0021622415)
n3:cisloPeriodika
4
n3:dodaniDat
n16:2010
n3:domaciTvurceVysledku
n4:6723381 n4:6659446
n3:druhVysledku
n6:J
n3:duvernostUdaju
n19:S
n3:entitaPredkladatele
n17:predkladatel
n3:idSjednocenehoVysledku
481109
n3:idVysledku
RIV/00216224:14310/06:00016118
n3:jazykVysledku
n12:eng
n3:klicovaSlova
AP-1; Jun; cancer; apoptosis; cell cycle; differentiation
n3:klicoveSlovo
n5:AP-1 n5:Jun n5:cell%20cycle n5:apoptosis n5:cancer n5:differentiation
n3:kodStatuVydavatele
CZ - Česká republika
n3:kontrolniKodProRIV
[0F2909FA0629]
n3:nazevZdroje
Journal of Applied Biomedicine
n3:obor
n14:EB
n3:pocetDomacichTvurcuVysledku
2
n3:pocetTvurcuVysledku
2
n3:projekt
n18:GA301%2F06%2F0036
n3:rokUplatneniVysledku
n16:2006
n3:svazekPeriodika
4
n3:tvurceVysledku
Šmarda, Jan Vaňhara, Petr
n3:zamer
n15:MSM0021622415
s:issn
1214-0287
s:numberOfPages
8
n8:organizacniJednotka
14310