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Statements

Subject Item
n2:RIV%2F00216224%3A14310%2F05%3A00028508%21RIV10-AV0-14310___
rdf:type
skos:Concept n13:Vysledek
dcterms:description
Replacement of one ammine in clinically ineffective trans-[PtCl2(NH3)2] (transplatin) by a planar N-heterocycle, thiazole, results in significantly enhanced cytotoxicity. Unlike %22classical%22 cisplatin {cis-[PtCl2(NH3)2]} or transplatin, modification of DNA by this prototypical cytotoxic transplatinum complex trans-[PtCl2(NH3)(thiazole)] (trans-PtTz) leads to monofunctional and bifunctional intra or interstrand adducts in roughly equal proportions. DNA fragments containing site-specific bifunctional DNA adducts of trans-PtTz were prepared. The structural distortions induced in DNA by these adducts and their consequences for high-mobility group protein recognition, DNA polymerization and nucleotide excision repair were assessed in cell-free media by biochemical methods. Whereas monofunctional adducts of trans-PtTz behave similar to the major intrastrand adduct of cisplatin [J. Kasparkova, O. Novakova, N. Farrell and V. Replacement of one ammine in clinically ineffective trans-[PtCl2(NH3)2] (transplatin) by a planar N-heterocycle, thiazole, results in significantly enhanced cytotoxicity. Unlike %22classical%22 cisplatin {cis-[PtCl2(NH3)2]} or transplatin, modification of DNA by this prototypical cytotoxic transplatinum complex trans-[PtCl2(NH3)(thiazole)] (trans-PtTz) leads to monofunctional and bifunctional intra or interstrand adducts in roughly equal proportions. DNA fragments containing site-specific bifunctional DNA adducts of trans-PtTz were prepared. The structural distortions induced in DNA by these adducts and their consequences for high-mobility group protein recognition, DNA polymerization and nucleotide excision repair were assessed in cell-free media by biochemical methods. Whereas monofunctional adducts of trans-PtTz behave similar to the major intrastrand adduct of cisplatin [J. Kasparkova, O. Novakova, N. Farrell and V.
dcterms:title
Conformation, protein recognition and repair of DNA interstrand and intrastrand cross-links of antitumor trans-[PtCl2(NH3)(thiazole)] Conformation, protein recognition and repair of DNA interstrand and intrastrand cross-links of antitumor trans-[PtCl2(NH3)(thiazole)]
skos:prefLabel
Conformation, protein recognition and repair of DNA interstrand and intrastrand cross-links of antitumor trans-[PtCl2(NH3)(thiazole)] Conformation, protein recognition and repair of DNA interstrand and intrastrand cross-links of antitumor trans-[PtCl2(NH3)(thiazole)]
skos:notation
RIV/00216224:14310/05:00028508!RIV10-AV0-14310___
n3:aktivita
n14:Z n14:P
n3:aktivity
P(1QS500040581), P(GA305/05/2030), P(IAA5004101), P(KJB5004301), P(NR8562), Z(AV0Z50040507)
n3:cisloPeriodika
18
n3:dodaniDat
n6:2010
n3:domaciTvurceVysledku
n7:2087960 n7:7988346 n7:5105307 n7:4571932
n3:druhVysledku
n17:J
n3:duvernostUdaju
n12:S
n3:entitaPredkladatele
n9:predkladatel
n3:idSjednocenehoVysledku
516190
n3:idVysledku
RIV/00216224:14310/05:00028508
n3:jazykVysledku
n19:eng
n3:klicovaSlova
platinum complexes; DNA; antitumor
n3:klicoveSlovo
n10:antitumor n10:platinum%20complexes n10:DNA
n3:kodStatuVydavatele
GB - Spojené království Velké Británie a Severního Irska
n3:kontrolniKodProRIV
[057C20F9EF8A]
n3:nazevZdroje
Nucleic Acids Research
n3:obor
n8:BO
n3:pocetDomacichTvurcuVysledku
4
n3:pocetTvurcuVysledku
6
n3:projekt
n4:1QS500040581 n4:GA305%2F05%2F2030 n4:IAA5004101 n4:KJB5004301 n4:NR8562
n3:rokUplatneniVysledku
n6:2005
n3:svazekPeriodika
33
n3:tvurceVysledku
Nováková, Olga Brabec, Viktor Marini Palomeque, María Victoria Farrell, Nicholas Christofis, Petros Kašpárková, Jana
n3:zamer
n16:AV0Z50040507
s:issn
0305-1048
s:numberOfPages
10
n18:organizacniJednotka
14310