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Statements

Subject Item
n2:RIV%2F00216224%3A14310%2F05%3A00014618%21RIV06-MSM-14310___
rdf:type
n14:Vysledek skos:Concept
dcterms:description
Práce srovnává výtěžnost detekce specifických chromozomových abnormalit u 33 dětských pacientů s akutní leukémií pomocí techniky G-pruhování, FISH, CGH a HR-CGH. We report results from the study of 33 children with acute lymphoid (25) and myeloid (8) leukaemia. Karyotyping of bone marrow cells is an important step for the precise diagnosis and for the choice of the adequate treatment in leukaemic patients. Twenty six patients were examined in the time of diagnosis and seven in relapse. The cytogenetic analyses were performed on 24-hours bone marrow cells cultured in RPMI 1640 according to the standard methods. GTG banding technique revealed clonal karyotypic abnormalities in 45% (15) samples. Cytogenetic findings were confirmed by fluorescence in situ hybridization (FISH) method. Comparative genomic hybridization (CGH) was used on bone marrow samples obtained from this patients in time of diagnosis or relapse. CGH showed new DNA copy number changes in 70% (23) patients. For the first time we were tested the modification of CGH. We show examples of submicroscopic chromosomal imbalances being detected with this high resolution CGH technique (HR-CGH). By HR- We report results from the study of 33 children with acute lymphoid (25) and myeloid (8) leukaemia. Karyotyping of bone marrow cells is an important step for the precise diagnosis and for the choice of the adequate treatment in leukaemic patients. Twenty six patients were examined in the time of diagnosis and seven in relapse. The cytogenetic analyses were performed on 24-hours bone marrow cells cultured in RPMI 1640 according to the standard methods. GTG banding technique revealed clonal karyotypic abnormalities in 45% (15) samples. Cytogenetic findings were confirmed by fluorescence in situ hybridization (FISH) method. Comparative genomic hybridization (CGH) was used on bone marrow samples obtained from this patients in time of diagnosis or relapse. CGH showed new DNA copy number changes in 70% (23) patients. For the first time we were tested the modification of CGH. We show examples of submicroscopic chromosomal imbalances being detected with this high resolution CGH technique (HR-CGH). By HR-
dcterms:title
The yield of chromosomal aberrations in children with acute leukemia using methods GTG banding, FISH, CGH and HR-CGH The yield of chromosomal aberrations in children with acute leukemia using methods GTG banding, FISH, CGH and HR-CGH Chromozomové aberace u dětí s akutní leukémií studované pomocí technik G-pruhování, fluorescenční hybridizace in situ, komparativní genomové hybridizace a komparativní genomové hybridizace s vysokým rozlišením
skos:prefLabel
The yield of chromosomal aberrations in children with acute leukemia using methods GTG banding, FISH, CGH and HR-CGH Chromozomové aberace u dětí s akutní leukémií studované pomocí technik G-pruhování, fluorescenční hybridizace in situ, komparativní genomové hybridizace a komparativní genomové hybridizace s vysokým rozlišením The yield of chromosomal aberrations in children with acute leukemia using methods GTG banding, FISH, CGH and HR-CGH
skos:notation
RIV/00216224:14310/05:00014618!RIV06-MSM-14310___
n3:strany
187
n3:aktivita
n18:Z
n3:aktivity
Z(MSM0021622415)
n3:cisloPeriodika
Suppl. 1
n3:dodaniDat
n12:2006
n3:domaciTvurceVysledku
n4:6933300 n4:9243682 n4:1398954 n4:5283752
n3:druhVysledku
n16:J
n3:duvernostUdaju
n17:S
n3:entitaPredkladatele
n8:predkladatel
n3:idSjednocenehoVysledku
551628
n3:idVysledku
RIV/00216224:14310/05:00014618
n3:jazykVysledku
n9:eng
n3:klicovaSlova
Acute leukemia; chromosome aberrations; cytogenetics; FISH; CGH; HR-CGH
n3:klicoveSlovo
n5:HR-CGH n5:CGH n5:FISH n5:chromosome%20aberrations n5:Acute%20leukemia n5:cytogenetics
n3:kodStatuVydavatele
CZ - Česká republika
n3:kontrolniKodProRIV
[437705237263]
n3:nazevZdroje
European Journal of Human Genetics
n3:obor
n15:EB
n3:pocetDomacichTvurcuVysledku
4
n3:pocetTvurcuVysledku
10
n3:rokUplatneniVysledku
n12:2005
n3:svazekPeriodika
13
n3:tvurceVysledku
Vranová, Vladimíra Mentzlová, Dita Mendelová, Denisa Oltová, Alexandra Linková, Vlasta Filková, Hana Žežulková, Dita Pešáková, Martina Štěrba, Jaroslav Kuglík, Petr
n3:zamer
n13:MSM0021622415
s:issn
1018-4813
s:numberOfPages
1
n10:organizacniJednotka
14310