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Statements

Subject Item
n2:RIV%2F00216224%3A14310%2F05%3A00012382%21RIV10-MSM-14310___
rdf:type
skos:Concept n20:Vysledek
dcterms:description
In order to investigate the versatility of proteome of leukemic cells undergoing terminal differentiation, we performed two-dimensional electrophoresis of proteins extracted from BM2 monoblasts induced differentiation inducers TPA and TSA for various time periods and compared it with two-dimensional electrophoretogram of untreated control cells. Similar analyses were performed with BM2RAR cells upon induction with retinoic acid. Some of the spots of differentially expressed proteins were digested with trypsin and identified by MALDI-TOF mass spectrometry as heat shock protein 70, protein-glutamine glutamyltransferase 4, prostaglandin-D-synthase, EMS1, nucleobindin 2 precursor (DNA-binding protein NEFA), actin, ARP2/3 protein complex subunit 3 and chaperonin Hsp60. Biological significance of versatility of these proteins in differentiating BM2 cells is currently investigated. In order to investigate the versatility of proteome of leukemic cells undergoing terminal differentiation, we performed two-dimensional electrophoresis of proteins extracted from BM2 monoblasts induced differentiation inducers TPA and TSA for various time periods and compared it with two-dimensional electrophoretogram of untreated control cells. Similar analyses were performed with BM2RAR cells upon induction with retinoic acid. Some of the spots of differentially expressed proteins were digested with trypsin and identified by MALDI-TOF mass spectrometry as heat shock protein 70, protein-glutamine glutamyltransferase 4, prostaglandin-D-synthase, EMS1, nucleobindin 2 precursor (DNA-binding protein NEFA), actin, ARP2/3 protein complex subunit 3 and chaperonin Hsp60. Biological significance of versatility of these proteins in differentiating BM2 cells is currently investigated.
dcterms:title
Versatility of proteome during terminal differentiation of v-myb-transformed monoblasts Versatility of proteome during terminal differentiation of v-myb-transformed monoblasts
skos:prefLabel
Versatility of proteome during terminal differentiation of v-myb-transformed monoblasts Versatility of proteome during terminal differentiation of v-myb-transformed monoblasts
skos:notation
RIV/00216224:14310/05:00012382!RIV10-MSM-14310___
n4:aktivita
n16:P n16:Z
n4:aktivity
P(GA301/03/1055), Z(MSM0021622415)
n4:dodaniDat
n5:2010
n4:domaciTvurceVysledku
n11:9039058 n11:6659446 n11:5687683 n11:4568567 n11:9091211 n11:9725741
n4:druhVysledku
n7:D
n4:duvernostUdaju
n18:S
n4:entitaPredkladatele
n15:predkladatel
n4:idSjednocenehoVysledku
548732
n4:idVysledku
RIV/00216224:14310/05:00012382
n4:jazykVysledku
n9:eng
n4:klicovaSlova
proteom; v-Myb; diferenciace; hmotnostní spektrometrie; dvourozměrná elektroforéza
n4:klicoveSlovo
n6:diferenciace n6:dvourozm%C4%9Brn%C3%A1%20elektrofor%C3%A9za n6:hmotnostn%C3%AD%20spektrometrie n6:v-Myb n6:proteom
n4:kontrolniKodProRIV
[358EB779F0D4]
n4:mistoKonaniAkce
Brno
n4:mistoVydani
Brno
n4:nazevZdroje
Sborník příspěvků IX. pracovního setkání biochemiků a molekulárních biologů
n4:obor
n22:EB
n4:pocetDomacichTvurcuVysledku
6
n4:pocetTvurcuVysledku
6
n4:projekt
n12:GA301%2F03%2F1055
n4:rokUplatneniVysledku
n5:2005
n4:tvurceVysledku
Černá, Karolína Šmarda, Jan Konečná, Hana Ondroušková, Eva Váňa, Petr Zdráhal, Zbyněk
n4:typAkce
n19:CST
n4:zahajeniAkce
2005-02-09+01:00
n4:zamer
n14:MSM0021622415
s:numberOfPages
2
n21:hasPublisher
Masarykova univerzita v Brně
n13:isbn
80-210-3635-4
n3:organizacniJednotka
14310